Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 7/20 | 0.44 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.43 |
| ▸ | KDM6B | O15054 | 4/20 | 0.41 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ASPH | Q12797 | 1/20 | 0.37 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.37 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.37 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19689691 | 0.84 | KMT2A (0.49) | KDM4CCLCN2KDM6BGRIK1KEAP1 | |
| SCHEMBL3640375 | 0.82 | KDM4E (0.49) | KDM4CCLCN2KDM6BALDH1A1HPGD | |
| SCHEMBL15638826 | 0.80 | GRIK1 (0.46) | KDM4CCLCN2KDM6BGRIK1KEAP1 | |
| SCHEMBL3513043 | 0.79 | ADRA1A (0.37) | KDM4EGAA | |
| SCHEMBL13921285 | 0.79 | CLCN2 (0.49) | KDM4CCLCN2KDM6BGRIK1KEAP1 | |
| SCHEMBL9744548 | 0.79 | CLCN2 (0.46) | KDM4CCLCN2GRIK1KEAP1ALDH1A1 | |
| SCHEMBL27785055 | 0.77 | ALDH1A1 (0.35) | ALDH1A1HSD17B10KDM4EGAA | |
| SCHEMBL9745145 | 0.75 | HCAR3 (0.45) | KDM4CCLCN2GRIK1KEAP1ALDH1A1 | |
| SCHEMBL1147582 | 0.75 | KDM4C (0.56) | KDM4CKDM6BALDH1A1HPGDHSD17B10 | |
| SCHEMBL15636197 | 0.74 | KDM6B (0.54) | KDM4CKDM6BKEAP1KDM4EPLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176231-A1 | SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2010-04-21 | — | — | EP | disclosed |
| WO-2009013126-A1 | SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2009-01-29 | — | — | WO | disclosed |