SCHEMBL3640412

CC(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(CC(C)(C)O)(c2ccccc2)OC1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 4)

	gene	UniProt	supporting neighbours	confidence
▸	HSD11B1	P28845	20/20	1.00

▸	CYP2C9	P11712	14/20	1.00

▸	CYP3A4	P08684	10/20	1.00

▸	CYP2C19	P33261	7/20	1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL958100	1.00	HSD11B1 (1.00)	HSD11B1CYP2C9CYP3A4CYP2C19
SCHEMBL734890	1.00	HSD11B1 (1.00)	HSD11B1CYP2C9CYP3A4CYP2C19
SCHEMBL959352	0.97	HSD11B1 (0.94)	HSD11B1CYP2C9CYP3A4CYP2C19
SCHEMBL959350	0.97	HSD11B1 (0.94)	HSD11B1CYP2C9CYP3A4CYP2C19
SCHEMBL960295	0.92	HSD11B1 (0.90)	HSD11B1CYP2C9CYP3A4CYP2C19
SCHEMBL960294	0.92	HSD11B1 (0.90)	HSD11B1CYP2C9CYP3A4CYP2C19
SCHEMBL735685	0.91	HSD11B1 (0.94)	HSD11B1CYP2C9CYP3A4CYP2C19
SCHEMBL958720	0.91	HSD11B1 (0.83)	HSD11B1CYP2C9CYP3A4CYP2C19
SCHEMBL958721	0.91	HSD11B1 (0.83)	HSD11B1CYP2C9CYP3A4CYP2C19
SCHEMBL12035249	0.90	HSD11B1 (0.81)	HSD11B1CYP2C9CYP3A4CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2183228-A1	CYCLIC INHIBITORS OF 11ß -HYDROXYSTERIOD DEHYDROGENASE 1	Vitae Pharmaceuticals, Inc. (US)	2010-05-12	—	—	EP	claimed
WO-2009017664-A1	CYCLIC INHIBITORS OF 11β-HYDROXYSTERIOD DEHYDROGENASE 1	VITAE PHARMACEUTICALS, INC. (US)	2009-02-05	—	—	WO	claimed