Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 15/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL363234 | 0.84 | PDE10A (0.56) | PDE10ACYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL364061 | 0.78 | PDE10A (0.66) | PDE10A | |
| SCHEMBL361777 | 0.74 | PDE10A (0.68) | PDE10AMAPK1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL363902 | 0.68 | PDE10A (0.67) | PDE10APDE5APDE1BPDE4DPDE3A | |
| SCHEMBL363852 | 0.67 | PDE10A (1.00) | PDE10APDE5APDE1BPDE4DPDE3A | |
| SCHEMBL363353 | 0.64 | PDE10A (1.00) | PDE10APDE5APDE1BPDE4DPDE3A | |
| SCHEMBL370906 | 0.64 | PDE10A (0.71) | PDE10ASMN1; SMN2 | |
| SCHEMBL28265975 | 0.64 | NPY5R (0.62) | — | |
| SCHEMBL364694 | 0.61 | PDE10A (1.00) | PDE10APDE5APDE1BPDE4DPDE3A | |
| SCHEMBL16324218 | 0.60 | NPY5R (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007006-A1 | TRIAZOLO- AND PYRAZOLOQUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITOR | H. LUNDBECK A/S (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007006-A1 | TRIAZOLO- AND PYRAZOLOQUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITOR | H. LUNDBECK A/S (DK) | 2012-01-19 | — | — | WO | disclosed |