Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.55 |
| ▸ | HPGD | P15428 | 5/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL369760 | 0.83 | PDE10A (1.00) | PDE10AALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL363902 | 0.77 | PDE10A (0.67) | PDE10A | |
| SCHEMBL363830 | 0.72 | PDE10A (0.69) | PDE10AALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL361777 | 0.71 | PDE10A (0.68) | PDE10AALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL368463 | 0.71 | PDE10A (0.78) | PDE10A | |
| SCHEMBL260106 | 0.70 | PDE10A (1.00) | PDE10AALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL369825 | 0.68 | PDE10A (0.53) | PDE10AKDM4ENPC1PKMRAB9A | |
| SCHEMBL370737 | 0.67 | PDE10A (1.00) | PDE10ANPC1SMN1; SMN2RAB9A | |
| SCHEMBL363353 | 0.65 | PDE10A (1.00) | PDE10A | |
| SCHEMBL364056 | 0.64 | PDE10A (0.50) | PDE10ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007006-A1 | TRIAZOLO- AND PYRAZOLOQUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITOR | H. LUNDBECK A/S (DK) | 2012-01-19 | — | — | WO | claimed |