Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 11/20 | 0.78 |
| ▸ | NR3C2 | P08235 | 9/20 | 0.78 |
| ▸ | PGR | P06401 | 6/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CCR10 | P46092 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3774636 | 1.00 | NR3C1 (0.78) | NR3C1NR3C2PGRCYP3A4ALDH1A1 | |
| SCHEMBL3766824 | 0.88 | NR3C1 (1.00) | NR3C1NR3C2PGRCYP3A4ALDH1A1 | |
| SCHEMBL3647266 | 0.87 | NR3C1 (0.76) | NR3C1NR3C2PGRCYP3A4CCR10 | |
| SCHEMBL3642644 | 0.87 | NR3C1 (0.76) | NR3C1NR3C2PGRCYP3A4CCR10 | |
| SCHEMBL3779016 | 0.85 | NR3C2 (0.66) | NR3C1NR3C2PGRCYP3A4ALDH1A1 | |
| SCHEMBL3642260 | 0.85 | NR3C2 (0.66) | NR3C1NR3C2PGRCYP3A4ALDH1A1 | |
| SCHEMBL3638434 | 0.79 | NR3C1 (0.75) | NR3C1NR3C2PGRCYP3A4ALDH1A1 | |
| SCHEMBL13810701 | 0.76 | NR3C1 (0.57) | NR3C1NR3C2PGRCYP3A4CCR10 | |
| SCHEMBL3646763 | 0.75 | NR3C1 (0.68) | NR3C1NR3C2PGRCYP3A4SMN1; SMN2 | |
| SCHEMBL3641101 | 0.75 | NR3C1 (0.68) | NR3C1NR3C2PGRCYP3A4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183217-A2 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | Boehringer Ingelheim International GmbH (DE) | 2010-05-12 | — | — | EP | claimed |
| WO-2009015067-A2 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-01-29 | — | — | WO | claimed |
| EP-2183217-A2 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | Boehringer Ingelheim International GmbH (DE) | 2010-05-12 | — | — | EP | disclosed |
| WO-2009015067-A2 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-01-29 | — | — | WO | disclosed |