SCHEMBL3642636

SCHEMBL3642636

O=C(O)c1ccc(C(=O)Nc2cccnc2)cc1

nearest known ligand 0.81

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ NAMPT P43490 9/20 0.81
▸ RAB9A P51151 5/20 0.77
▸ NPC1 O15118 4/20 0.77
▸ LMNA P02545 2/20 0.77
▸ GAA P10253 1/20 0.77
▸ CYP11B1 P15538 5/20 0.74
▸ CYP11B2 P19099 5/20 0.74
▸ HIF1A Q16665 1/20 0.73
▸ TP53 P04637 1/20 0.71
▸ RECQL P46063 1/20 0.71
▸ TRPV1 Q8NER1 1/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL167081 0.90 NAMPT (1.00) NAMPTRAB9ANPC1LMNAGAA
Hydrochloric Acid SCHEMBL27890956 0.88 NAMPT (0.97) NAMPTRAB9ANPC1LMNAGAA
SCHEMBL5435462 0.87 NAMPT (0.76) NAMPTRAB9ANPC1LMNAGAA
SCHEMBL28007807 0.86 NAMPT (0.81) NAMPTRAB9ANPC1LMNAGAA
SCHEMBL95793 0.85 NAMPT (0.73) NAMPTRAB9ANPC1LMNAGAA
SCHEMBL6354168 0.85 CYP11B1 (1.00) NAMPTRAB9ANPC1LMNAGAA
SCHEMBL12078341 0.85 NAMPT (0.77) NAMPTRAB9ANPC1LMNAGAA
SCHEMBL30582756 0.85 CYP11B1 (1.00) NAMPTRAB9ANPC1LMNAGAA
SCHEMBL3403542 0.85 NAMPT (0.73) NAMPTRAB9ANPC1LMNAGAA
SCHEMBL5450085 0.85 NAMPT (0.73) NAMPTRAB9ANPC1LMNAGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3049387-B1 THERMOPLASTIC POLYMER COMPOSITION MILLIKEN & CO (US) 2020-11-11 — — EP disclosed
EP-3049387-B1 THERMOPLASTIC POLYMER COMPOSITION MILLIKEN & CO (US) 2020-11-11 — — EP disclosed
US-9200142-B2 Thermoplastic polymer composition MILLIKEN & COMPANY (US) 2015-12-01 — — US disclosed
US-9200144-B2 Thermoplastic polymer composition MILLIKEN & COMPANY (US) 2015-12-01 — — US disclosed
US-9193845-B2 Thermoplastic polymer composition MILLIKEN & COMPANY (US) 2015-11-24 — — US disclosed
US-9120914-B2 Thermoplastic polymer composition MILLIKEN & COMPANY (US) 2015-09-01 — — US disclosed
US-20150094406-A1 THERMOPLASTIC POLYMER COMPOSITION MILLIKEN & COMPANY 2015-04-02 — — US disclosed
WO-2015042565-A1 THERMOPLASTIC POLYMER COMPOSITION MILLIKEN & COMPANY (US) 2015-03-26 — — WO disclosed
WO-2015042562-A1 THERMOPLASTIC POLYMER COMPOSITION MILLIKEN & COMPANY (US) 2015-03-26 — — WO disclosed
US-20150087758-A1 THERMOPLASTIC POLYMER COMPOSITION MILLIKEN & COMPANY 2015-03-26 — — US disclosed
WO-2015042563-A1 THERMOPLASTIC POLYMER COMPOSITION MILLIKEN & COMPANY (US) 2015-03-26 — — WO disclosed
WO-2015042561-A1 THERMOPLASTIC POLYMER COMPOSITION MILLIKEN & COMPANY (US) 2015-03-26 — — WO disclosed
US-20150087759-A1 THERMOPLASTIC POLYMER COMPOSITION MILLIKEN & COMPANY 2015-03-26 — — US disclosed
US-20150087757-A1 THERMOPLASTIC POLYMER COMPOSITION MILLIKEN & COMPANY 2015-03-26 — — US disclosed
EP-2167077-A2 ARYL/HETARYLAMIDES AS MODULATORS OF THE EP2 RECEPTOR Bayer Schering Pharma Aktiengesellschaft (DE) 2010-03-31 — — EP disclosed
US-20090023741-A1 ARYL/HETARYLAMIDES AS MODULATORS OF THE EP2 RECEPTOR BAYER SCHERING PHARMA AG (DE) 2009-01-22 — — US disclosed
WO-2008152099-A2 ARYL/HETARYLAMIDES AS MODULATORS OF THE EP2 RECEPTOR BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2008-12-18 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150087757-A1 THERMOPLASTIC POLYMER COMPOSITION PARG, PUF60, MCM7 NAMPT 1248/4885RAB9A 4453/4885NPC1 1837/4885
US-20090023741-A1 ARYL/HETARYLAMIDES AS MODULATORS OF THE EP2 RECEPTOR PTGER2, PTGER1, PTGDR2 NAMPT 2055/4885RAB9A 3569/4885NPC1 1069/4885
US-20150087758-A1 THERMOPLASTIC POLYMER COMPOSITION ERCC4, SMCHD1, XRCC5 NAMPT 861/4885RAB9A 4597/4885NPC1 2858/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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