Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17242112 | 0.85 | MEN1 (0.53) | KMT2AMEN1ACHENPC1KIF11 | |
| SCHEMBL27282197 | 0.84 | KMT2A (0.57) | KMT2AMEN1ACHENPC1TDP1 | |
| SCHEMBL5682633 | 0.82 | ACHE (0.61) | KMT2AMEN1ACHETDP1CYP3A4 | |
| SCHEMBL11614660 | 0.82 | ACHE (0.47) | KMT2AMEN1TSHRCASP1ACHE | |
| SCHEMBL5697552 | 0.82 | MEN1 (0.59) | KMT2AMEN1CASP1NPC1KIF11 | |
| SCHEMBL31474585 | 0.81 | KMT2A (0.53) | KMT2AMEN1ACHENPC1KIF11 | |
| SCHEMBL14543275 | 0.81 | KMT2A (0.53) | KMT2AMEN1TSHRCASP1ACHE | |
| SCHEMBL27565314 | 0.79 | KMT2A (0.52) | KMT2AMEN1ACHENPC1KIF11 | |
| SCHEMBL7170047 | 0.79 | MEN1 (0.52) | KMT2AMEN1ACHENPC1L3MBTL1 | |
| SCHEMBL31266502 | 0.79 | MEN1 (0.52) | KMT2AMEN1ACHENPC1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2162445-A1 | HETEROBICYCLIC COMPOUNDS AS KINASE INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2010-03-17 | — | — | EP | disclosed |
| WO-2008150015-A1 | HETEROBICYCLIC COMPOUNDS AS KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-12-11 | — | — | WO | disclosed |