Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3651843 | 0.84 | PIK3CA (0.39) | PIK3CAMTORCDK9DYRK1ADYRK2 | |
| SCHEMBL3648302 | 0.84 | PIK3CA (0.43) | PIK3CAMTORCDK9DYRK1ADYRK2 | |
| SCHEMBL3650827 | 0.83 | PDGFRB (0.42) | PIK3CAMTORNR1H4KCNH2PDGFRB | |
| SCHEMBL3651846 | 0.83 | PIK3CA (0.40) | PIK3CAMTORCDK9DYRK1ADYRK2 | |
| SCHEMBL3647338 | 0.82 | CYP11B2 (0.48) | PIK3CAMTORCDK9DYRK1ADYRK2 | |
| SCHEMBL3654292 | 0.79 | NR1H4 (0.36) | PIK3CAMTORNR1H4KCNH2PDGFRB | |
| SCHEMBL3652136 | 0.73 | PRKCI (0.43) | PIK3CAMTORNR1H4CSNK1DMAPK11 | |
| SCHEMBL3647060 | 0.72 | NR1H4 (0.42) | PIK3CAMTORNR1H4KCNH2SLC6A2 | |
| SCHEMBL3643516 | 0.70 | NR1H4 (0.41) | PIK3CAMTORNR1H4KCNH2SLC6A2 | |
| SCHEMBL3650993 | 0.70 | TP53 (0.41) | PIK3CAMTORNR1H4CYP11B2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185556-A1 | IMIDAZOPYRIDINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM | Wyeth a Corporation of the State of Delaware (US) | 2010-05-19 | — | — | EP | disclosed |
| WO-2009029609-A1 | IMIDAZOPYRIDINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM | WYETH (US) | 2009-03-05 | — | — | WO | disclosed |