Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3013604 | 0.94 | GAA (0.50) | GAAKMT2AUSP2ALDH1A1RECQL | |
| SCHEMBL3016452 | 0.93 | GAA (0.51) | GAAKMT2AUSP2ALDH1A1RECQL | |
| SCHEMBL3647462 | 0.92 | ALDH1A1 (0.50) | GAAKMT2AUSP2ALDH1A1RECQL | |
| SCHEMBL3010047 | 0.90 | GAA (0.51) | GAAKMT2AUSP2ALDH1A1RECQL | |
| SCHEMBL3002376 | 0.87 | ALDH1A1 (0.51) | GAAKMT2AUSP2ALDH1A1RECQL | |
| SCHEMBL3651253 | 0.87 | ALDH1A1 (0.42) | KMT2AUSP2ALDH1A1RECQLMAPT | |
| SCHEMBL3013091 | 0.86 | GAA (0.51) | GAAKMT2AUSP2ALDH1A1RECQL | |
| SCHEMBL2997726 | 0.85 | GAA (0.52) | GAAKMT2AUSP2ALDH1A1RECQL | |
| SCHEMBL3007150 | 0.85 | GAA (0.49) | GAAKMT2AUSP2ALDH1A1RECQL | |
| SCHEMBL3018547 | 0.85 | GAA (0.40) | GAAKMT2AUSP2ALDH1A1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188272-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV Remynd (BE) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009019295-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2009-02-12 | — | — | WO | disclosed |