Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 6/20 | 0.50 |
| ▸ | HCRTR2 | O43614 | 6/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3647475 | 0.88 | HCRTR1 (0.51) | HCRTR1HCRTR2PTGS2 | |
| SCHEMBL3645275 | 0.85 | PIN1 (0.58) | HCRTR1HCRTR2ALOX5HPGDSMN1; SMN2 | |
| SCHEMBL3644934 | 0.83 | HCRTR1 (0.52) | HCRTR1HCRTR2ALOX5PIN1CYP3A4 | |
| SCHEMBL3648178 | 0.82 | HCRTR1 (0.51) | HCRTR1HCRTR2ALOX5HPGDSMN1; SMN2 | |
| SCHEMBL3645099 | 0.82 | HCRTR1 (0.51) | HCRTR1HCRTR2ALOX5HPGDSMN1; SMN2 | |
| SCHEMBL3649840 | 0.82 | HCRTR1 (0.48) | HCRTR1HCRTR2 | |
| SCHEMBL3640113 | 0.81 | HCRTR1 (0.50) | HCRTR1HCRTR2ALOX5HPGDSMN1; SMN2 | |
| SCHEMBL3646734 | 0.81 | HCRTR1 (0.55) | HCRTR1HCRTR2ALOX5HPGDSMN1; SMN2 | |
| SCHEMBL3640642 | 0.80 | HCRTR1 (0.49) | HCRTR1HCRTR2ALOX5CYP3A4 | |
| SCHEMBL3640315 | 0.79 | HCRTR1 (0.60) | HCRTR1HCRTR2PIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188282-A2 | 1,2-DIAMIDO-ETHYLENE DERIVATIVES AS OREXIN ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2010-05-26 | — | — | EP | claimed |
| WO-2009022311-A2 | 1,2-DIAMIDO-ETHYLENE DERIVATIVES AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2009-02-19 | — | — | WO | claimed |
| EP-2188282-B1 | 1,2-DIAMIDO-ETHYLENE DERIVATIVES AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-01-23 | — | — | EP | disclosed |
| EP-2188282-A2 | 1,2-DIAMIDO-ETHYLENE DERIVATIVES AS OREXIN ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009022311-A2 | 1,2-DIAMIDO-ETHYLENE DERIVATIVES AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2009-02-19 | — | — | WO | disclosed |