Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TLR4 | O00206 | 1/20 | 0.41 |
| ▸ | TLR2 | O60603 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1733997 | 0.87 | ALDH1A1 (0.52) | NPC1KMT2ARAB9ASMN1; SMN2CYP19A1 | |
| SCHEMBL30665870 | 0.87 | ALDH1A1 (0.52) | NPC1KMT2ARAB9ASMN1; SMN2CYP19A1 | |
| SCHEMBL7825236 | 0.79 | CYP19A1 (0.62) | NPC1KMT2ARAB9ASMN1; SMN2CYP19A1 | |
| SCHEMBL30665930 | 0.78 | TTR (0.54) | NPC1KMT2ARAB9ASMN1; SMN2CYP19A1 | |
| SCHEMBL22264774 | 0.78 | ALDH1A1 (0.51) | NPC1KMT2ARAB9ASMN1; SMN2CYP19A1 | |
| SCHEMBL31320855 | 0.78 | ALDH1A1 (0.51) | NPC1KMT2ARAB9ASMN1; SMN2CYP19A1 | |
| SCHEMBL1736331 | 0.78 | TTR (0.54) | NPC1KMT2ARAB9ASMN1; SMN2CYP19A1 | |
| SCHEMBL30549816 | 0.78 | ALDH1A1 (0.51) | NPC1KMT2ARAB9ASMN1; SMN2CYP19A1 | |
| SCHEMBL3649847 | 0.78 | ALDH1A1 (0.48) | NPC1KMT2ARAB9ASMN1; SMN2CYP19A1 | |
| SCHEMBL26654775 | 0.76 | ALDH1A1 (0.61) | NPC1KMT2ARAB9ASMN1; SMN2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194982-A1 | COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE | Glaxo Group Limited (GB) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009037294-A1 | COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2009-03-26 | — | — | WO | disclosed |