Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3018401 | 0.94 | GAA (0.48) | ALDH1A1PKMNPC1RAB9AGAA | |
| SCHEMBL3015128 | 0.92 | GAA (0.51) | ALDH1A1NPC1RAB9AGAAUSP2 | |
| SCHEMBL3652842 | 0.92 | ALDH1A1 (0.47) | ALDH1A1PKMNPC1RAB9AGAA | |
| SCHEMBL3015574 | 0.89 | GAA (0.51) | ALDH1A1PKMNPC1RAB9AGAA | |
| SCHEMBL3021724 | 0.88 | GAA (0.52) | ALDH1A1PKMNPC1RAB9AGAA | |
| SCHEMBL3003923 | 0.87 | GAA (0.49) | ALDH1A1PKMNPC1RAB9AGAA | |
| SCHEMBL3010047 | 0.87 | GAA (0.51) | ALDH1A1PKMNPC1RAB9AGAA | |
| SCHEMBL3003251 | 0.86 | ALDH1A1 (0.48) | ALDH1A1PKMNPC1RAB9AGAA | |
| SCHEMBL3006869 | 0.86 | ALDH1A1 (0.49) | ALDH1A1PKMGAAUSP2L3MBTL1 | |
| SCHEMBL3010666 | 0.86 | ALDH1A1 (0.48) | ALDH1A1NPC1RAB9AGAAUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188272-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV Remynd (BE) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009019295-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2009-02-12 | — | — | WO | disclosed |