Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL958982 | 0.87 | USP30 (0.45) | GFER | |
| SCHEMBL959817 | 0.87 | USP30 (0.45) | GFER | |
| SCHEMBL958980 | 0.78 | SSTR3 (0.42) | ALDH1A1SMN1; SMN2KMT2ASLC6A1 | |
| SCHEMBL13953692 | 0.77 | CHEK1 (0.36) | — | |
| SCHEMBL17604857 | 0.73 | BCHE (0.53) | GFERALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL20765861 | 0.73 | BCHE (0.53) | GFERALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL20766009 | 0.73 | BCHE (0.53) | GFERALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL28431639 | 0.69 | JAK3 (0.36) | BTKKMT2A | |
| SCHEMBL1439795 | 0.69 | JAK3 (0.36) | BTKKMT2A | |
| SCHEMBL958027 | 0.68 | CHRM4 (0.40) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183228-A1 | CYCLIC INHIBITORS OF 11ß -HYDROXYSTERIOD DEHYDROGENASE 1 | Vitae Pharmaceuticals, Inc. (US) | 2010-05-12 | — | — | EP | disclosed |
| WO-2009017664-A1 | CYCLIC INHIBITORS OF 11β-HYDROXYSTERIOD DEHYDROGENASE 1 | VITAE PHARMACEUTICALS, INC. (US) | 2009-02-05 | — | — | WO | disclosed |