Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 13/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ITK | Q08881 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28431639 | 1.00 | JAK3 (0.36) | JAK3CA1CA2JAK1CA12 | |
| SCHEMBL1439214 | 0.79 | MEN1 (0.48) | CA1CA2KMT2A | |
| SCHEMBL9937183 | 0.79 | MEN1 (0.48) | CA1CA2KMT2A | |
| SCHEMBL19391801 | 0.79 | L3MBTL1 (0.39) | KMT2A | |
| SCHEMBL2729026 | 0.79 | CA1 (0.42) | CA1CA2CA12CA9KMT2A | |
| SCHEMBL2240702 | 0.79 | CA1 (0.42) | CA1CA2CA12CA9KMT2A | |
| SCHEMBL1250472 | 0.78 | ALDH1A1 (0.35) | JAK3CA1CA2JAK1CA12 | |
| SCHEMBL28957283 | 0.78 | ITGB3 (0.39) | JAK3CA1CA2CA12CA9 | |
| SCHEMBL2730657 | 0.78 | LMNA (0.46) | CA1CA2CA12CA9KMT2A | |
| SCHEMBL28957279 | 0.78 | ITGB3 (0.39) | JAK3CA1CA2CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112300172-A | Bruton's tyrosine kinase inhibitors | 比奥根MA公司 | 2021-02-02 | — | — | CN | disclosed |
| CN-107011330-B | Bruton's tyrosine kinase inhibitors | 比奥根MA公司 | 2020-07-03 | — | — | CN | disclosed |
| EP-2473049-A1 | BRUTON'S TYROSINE KINASE INHIBITORS | Biogen Idec MA Inc. (US) | 2012-07-11 | — | — | EP | disclosed |
| WO-2011029046-A1 | BRUTON'S TYROSINE KINASE INHIBITORS | BIOGEN IDEC MA INC. (US) | 2011-03-10 | — | — | WO | disclosed |