Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.39 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2080974 | 0.84 | SMN1; SMN2 (0.42) | ALDH1A1SMN1; SMN2CYP1A2CYP2C9METAP1 | |
| SCHEMBL24801822 | 0.84 | SMN1; SMN2 (0.42) | ALDH1A1SMN1; SMN2CYP1A2CYP2C9METAP1 | |
| SCHEMBL3647188 | 0.84 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2CYP1A2CYP2C9METAP1 | |
| Hydrochloric Acid SCHEMBL5474129 | 0.78 | PIK3CA (0.43) | ALDH1A1SMN1; SMN2CYP2C9CYP3A4PIK3CA | |
| SCHEMBL9455812 | 0.78 | PIK3CA (0.43) | ALDH1A1SMN1; SMN2CYP1A2POLBCYP2C19 | |
| SCHEMBL1801712 | 0.78 | SMN1; SMN2 (0.58) | ALDH1A1SMN1; SMN2CYP1A2CYP2C9METAP1 | |
| Hydrochloric Acid SCHEMBL9455729 | 0.77 | PIK3CA (0.43) | ALDH1A1SMN1; SMN2CYP1A2CYP2C19PIK3CA | |
| Hydrochloric Acid SCHEMBL9455891 | 0.77 | PIK3CA (0.43) | ALDH1A1SMN1; SMN2CYP1A2CYP2C19PIK3CA | |
| SCHEMBL823332 | 0.75 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2CYP1A2CYP2C9METAP1 | |
| SCHEMBL24342393 | 0.75 | CYP1A2 (0.45) | ALDH1A1SMN1; SMN2CYP1A2CYP2C9METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100311748-A1 | HETEROCYCLIC AMIDES USEFUL FOR THE TREATMENT OF CANCER AND PSORIASIS | ASTRAZENECA AB (SE) | 2010-12-09 | — | — | US | disclosed |
| EP-2188255-A1 | HETEROCYCLIC AMIDES USEFUL FOR THE TREATMENT OF CANCER AND PSORIASIS | AstraZeneca AB (SE) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009027746-A1 | HETEROCYCLIC AMIDES USEFUL FOR THE TREATMENT OF CANCER AND PSORIASIS | ASTRAZENECA AB (SE) | 2009-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100311748-A1 | HETEROCYCLIC AMIDES USEFUL FOR THE TREATMENT OF CANCER AND PSORIASIS | SHH, GLI1, HRH4 | ALDH1A1 1711/4885SMN1; SMN2 4749/4885CYP1A2 1878/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.