Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fluorouracil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluorouracil SCHEMBL10017187 | 1.00 | — | — | |
| Fluorouracil SCHEMBL249289 | 1.00 | MAPT (1.00) | — | |
| Fluorouracil SCHEMBL7650203 | 0.97 | MAPT (0.95) | — | |
| Fluorouracil SCHEMBL31441196 | 0.97 | MAPT (0.95) | — | |
| Fluorouracil SCHEMBL30439198 | 0.97 | MAPT (0.95) | — | |
| Fluorouracil SCHEMBL15284932 | 0.97 | MAPT (0.95) | — | |
| Fluorouracil SCHEMBL11327829 | 0.97 | MAPT (0.95) | — | |
| Fluorouracil SCHEMBL21527805 | 0.97 | MAPT (0.95) | — | |
| Fluorouracil SCHEMBL21880166 | 0.97 | MAPT (0.95) | — | |
| Fluorouracil SCHEMBL28803776 | 0.97 | MAPT (0.95) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 331336 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12186394-B2 | Compositions and methods for treatment of pre-cancerous skin lesions | WASHINGTON UNIVERSITY (US) | 2025-01-07 | — | — | US | claimed |
| US-12187782-B2 | PDL1 peptides for use in cancer vaccines | IO BIOTECH APS (DK) | 2025-01-07 | — | — | US | claimed |
| EP-4484420-A1 | INHIBITOR OF INTERACTION BETWEEN YAP/TAZ AND TEAD, PREPARATION THEREOF, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF | Etern Biopharma (Shanghai) Co., Ltd. (CN) | 2025-01-01 | — | — | EP | claimed |
| CN-119185165-A | Controlled release medicine micro-needle with good biocompatibility and preparation method thereof | 上海市第一人民医院 | 2024-12-27 | — | — | CN | claimed |
| CN-119191955-A | Enantiomer-eudesmane sesquiterpenoids and application thereof | 海南师范大学 | 2024-12-27 | — | — | CN | claimed |
| US-20240425752-A1 | BILIRUBIN-COATED RADIO-LUMINESCENT PARTICLES | PURDUE RESEARCH FOUNDATION (US) | 2024-12-26 | — | — | US | claimed |
| US-20240423972-A1 | CHEMOTHERAPEUTIC BIOADHESIVE PARTICLES WITH IMMUNOSTIMULATORY MOLECULES FOR CANCER TREATMENT | YALE UNIVERSITY | 2024-12-26 | — | — | US | claimed |
| EP-4479034-A1 | CAPSAICIN DERIVATIVES AS BIOENHANCERS ON ACTIVE SUBSTANCES METABOLIZED BY CYP1A2 AND CYP2D6 | aXichem AB (SE) | 2024-12-25 | — | — | EP | claimed |
| US-12173039-B1 | TPL2 inhibiting agents, uses thereof, and detection of TPL2 | WASHINGTON UNIVERSITY (US) | 2024-12-24 | — | — | US | claimed |
| US-20240415972-A1 | MICROFRAGMENTED FAT TISSUE AS DRUG DELIVERY SYSTEM IN LIVER CANCER THERAPY | LIPOGEMS INT S P A (IT) | 2024-12-19 | — | — | US | claimed |
| US-3992522-A | INFLUENZA VIRUSES | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH, EDUCATION AND WELFARE (US) | 1976-11-16 | — | — | US | claimed |
| US-3992208-A | Photo-sensitive etchant and method for forming metal image using same | FUJI PHOTO FILM CO., LTD. (JA) | 1976-11-16 | — | — | US | claimed |
| US-3991203-A | Vehicle composition containing 1-substituted azacyclopentan-2-ones | NELSON RESEARCH & DEVELOPMENT COMPANY (US) | 1976-11-09 | — | — | US | claimed |
| US-3989815-A | PENETRATION OF SKINS | NELSON RESEARCH & DEVELOPMENT COMPANY (US) | 1976-11-02 | — | — | US | claimed |
| US-3989816-A | PENETRATION OF SKINS OR MEMBRANES | NELSON RESEARCH & DEVELOPMENT COMPANY (US) | 1976-11-02 | — | — | US | claimed |
| US-3971784-A | ANTIMETABOLITES | MITSUI PHARMACEUTICALS, INCORPORATED (JA) | 1976-07-27 | — | — | US | claimed |
| US-3966924-A | B-METHASONE VALERATE, 5-FLUOROURACIL | ALLERGAN PHARMACEUTICALS (US) | 1976-06-29 | — | — | US | claimed |
| US-3960864-A | Method of synthesizing 1-(tetrahydro-2-furanyl)-5-fluorouracil | THE UNIVERSITY OF UTAH (US) | 1976-06-01 | — | — | US | claimed |
| US-3954536-A | 5-FLUORO-URACIL, GLUCOSE, GLYCERIN | LIQUICHIMICA S.P.A. (IT) | 1976-05-04 | — | — | US | claimed |
| US-3954758-A | GERMICIDES, CANCER CHEMOTHERAPY | PCR, INC. (US) | 1976-05-04 | — | — | US | claimed |