Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 7/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5671564 | 0.91 | EPHX1 (0.40) | EPHX1ACHEMAPTALDH1A1RECQL | |
| SCHEMBL14620243 | 0.87 | EPHX1 (0.37) | EPHX1ACHEMAPTALDH1A1RECQL | |
| SCHEMBL2707882 | 0.81 | SMN1; SMN2 (0.33) | SMN1; SMN2CA1CA2CYP2C19 | |
| SCHEMBL6505996 | 0.76 | TSHR (0.47) | EPHX1ACHEMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL13218914 | 0.75 | EPHX1 (0.46) | EPHX1ACHEALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL20683487 | 0.75 | CA1 (0.46) | EPHX1ACHEALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL1696818 | 0.75 | CA1 (0.46) | EPHX1ACHEALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL5622460 | 0.74 | EPHX1 (0.48) | EPHX1ACHEALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL2344660 | 0.73 | EPHX1 (0.44) | EPHX1ACHEALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL16760 | 0.73 | CA12 (0.41) | CA1CA2CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170081363-A1 | PHARMACEUTICALLY RELEVANT AROMATIC-CATIONIC PEPTIDES | STEALTH BIOTHERAPEUTICS CORP (MC) | 2017-03-23 | — | — | US | disclosed |
| US-20160340389-A1 | PHARMACEUTICALLY RELEVANT AROMATIC-CATIONIC PEPTIDES | STEALTH BIOTHERAPEUTICS INC. | 2016-11-24 | — | — | US | disclosed |
| WO-2015134096-A1 | PHARMACEUTICALLY RELEVANT AROMATIC-CATIONIC PEPTIDES | STEALTH PEPTIDES INTERNATIONAL, INC. (MC) | 2015-09-11 | — | — | WO | disclosed |
| EP-2190824-A1 | NAPHTHYLPYRIMIDINE, NAPHTHYLPYRAZINE AND NAPHTHYLPYRIDAZINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM | Wyeth a Corporation of the State of Delaware (US) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009026319-A1 | NAPHTHYLPYRIMIDINE, NAPHTHYLPYRAZINE AND NAPHTHYLPYRIDAZINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM | WYETH (US) | 2009-02-26 | — | — | WO | disclosed |
| WO-2009026326-A1 | NAPHTHYLPYRIMIDINE, NAPHTHYLPYRAZINE AND NAPHTHYLPYRIDAZINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM | WYETH (US) | 2009-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160340389-A1 | PHARMACEUTICALLY RELEVANT AROMATIC-CATIONIC PEPTIDES | ADM2, VIP, ANPEP | EPHX1 4689/4885ACHE 3859/4885MAPT 506/4885 |
| US-20170081363-A1 | PHARMACEUTICALLY RELEVANT AROMATIC-CATIONIC PEPTIDES | ADM2, VIP, ANPEP | EPHX1 4544/4885ACHE 4004/4885MAPT 459/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.