Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 10/20 | 0.67 |
| ▸ | PDE7B | Q9NP56 | 5/20 | 0.61 |
| ▸ | PDE8A | O60658 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | OXTR | P30559 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL100515 | 0.94 | PDE7A (0.66) | PDE7APDE7BPDE8ANPC1RAB9A | |
| SCHEMBL14782104 | 0.94 | PDE7A (0.65) | PDE7APDE7BPDE8ANPC1RAB9A | |
| SCHEMBL17416742 | 0.92 | PDE7A (0.60) | PDE7APDE7BPDE8ANPC1RAB9A | |
| SCHEMBL99965 | 0.91 | PDE7A (0.62) | PDE7APDE7BPDE8ANPC1RAB9A | |
| SCHEMBL100114 | 0.90 | PDE7A (0.80) | PDE7APDE7BPDE8ANPC1RAB9A | |
| SCHEMBL2683924 | 0.88 | PDE7A (0.63) | PDE7APDE7BPDE8ANPC1RAB9A | |
| SCHEMBL133527 | 0.88 | PDE7A (0.63) | PDE7APDE7BPDE8ANPC1RAB9A | |
| SCHEMBL582570 | 0.88 | PDE7A (0.77) | PDE7APDE7BPDE8ANPC1RAB9A | |
| SCHEMBL14775916 | 0.88 | PDE7A (0.60) | PDE7APDE7BPDE8ANPC1RAB9A | |
| SCHEMBL582751 | 0.87 | PDE7A (0.62) | PDE7APDE7BPDE8ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205593-B1 | QUINAZOLINEDIONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USES THEREOF | SANOFI SA (FR) | 2016-01-13 | — | — | EP | disclosed |
| EP-2416777-B1 | THERAPEUTIC APPLICATIONS IN THE CARDIOVASCULAR FIELD OF QUINAZOLINEDIONE DERIVATIVES | SANOFI SA (FR) | 2014-11-12 | — | — | EP | disclosed |
| CN-102458409-B | Therapeutic applications in the cardiovascular field of quinazolinedione derivatives | SANOFI AVENTIS | 2014-06-18 | — | — | CN | disclosed |
| EP-2411009-B1 | Therapeutic uses of quinazolinedione derivatives | SANOFI SA (FR) | 2013-03-20 | — | — | EP | disclosed |
| WO-2010116090-A1 | THERAPEUTIC APPLICATIONS IN THE CARDIOVASCULAR FIELD OF QUINAZOLINEDIONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2010-10-14 | — | — | WO | disclosed |
| WO-2010109148-A1 | THERAPEUTIC USES OF QUINAZOLINEDIONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2010-09-30 | — | — | WO | disclosed |
| EP-2205593-A1 | QUINAZOLINEDIONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USES THEREOF | Sanofi-Aventis (FR) | 2010-07-14 | — | — | EP | disclosed |
| WO-2009077680-A1 | QUINAZOLINEDIONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USES THEREOF | SANOFI-AVENTIS (FR) | 2009-06-25 | — | — | WO | disclosed |
| WO-2009077680-A1 | QUINAZOLINEDIONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USES THEREOF | SANOFI-AVENTIS (FR) | 2009-06-25 | — | — | WO | disclosed |