Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 10/20 | 0.60 |
| ▸ | PDE7B | Q9NP56 | 5/20 | 0.59 |
| ▸ | PDE8A | O60658 | 3/20 | 0.59 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL100580 | 0.93 | PDE7A (0.60) | PDE7APDE7BPDE8AFEN1ESR1 | |
| SCHEMBL17416726 | 0.91 | PDE7A (0.55) | PDE7APDE7BPDE8AFEN1TSHR | |
| SCHEMBL474204 | 0.90 | PDE7A (0.59) | PDE7APDE7BPDE8AFEN1TSHR | |
| SCHEMBL99845 | 0.90 | PDE7A (0.62) | PDE7APDE7BPDE8AFEN1TSHR | |
| SCHEMBL100025 | 0.89 | PDE7A (0.56) | PDE7APDE7BPDE8ATSHR | |
| SCHEMBL173169 | 0.88 | PDE7A (0.56) | PDE7APDE7BPDE8AFEN1ESR1 | |
| SCHEMBL3649285 | 0.88 | PDE7A (0.67) | PDE7APDE7BPDE8ATSHRNPC1 | |
| SCHEMBL99714 | 0.88 | PDE7A (0.76) | PDE7APDE7BPDE8ATSHRESR1 | |
| SCHEMBL585427 | 0.87 | PDE7A (0.76) | PDE7APDE7BPDE8ATSHRKDM4E | |
| SCHEMBL173189 | 0.86 | PDE7A (0.57) | PDE7APDE7BPDE8AFEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411009-B1 | Therapeutic uses of quinazolinedione derivatives | SANOFI SA (FR) | 2013-03-20 | — | — | EP | disclosed |