Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | USP2 | O75604 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3015047 | 0.97 | MAPT (0.51) | REV1MAPTUSP2RECQLHSD17B10 | |
| SCHEMBL3018032 | 0.97 | REV1 (0.53) | REV1MAPTUSP2RECQLHSD17B10 | |
| SCHEMBL3017437 | 0.89 | KMT2A (0.51) | MAPTUSP2RECQLHSD17B10AR | |
| SCHEMBL3771577 | 0.86 | REV1 (0.47) | REV1MAPTUSP2RECQLHSD17B10 | |
| SCHEMBL3011256 | 0.85 | MAPT (0.51) | REV1MAPTUSP2RECQLHSD17B10 | |
| SCHEMBL3006754 | 0.85 | REV1 (0.56) | REV1MAPTUSP2RECQLHSD17B10 | |
| SCHEMBL3010407 | 0.84 | REV1 (0.57) | REV1MAPTUSP2RECQLHSD17B10 | |
| SCHEMBL3010901 | 0.84 | KMT2A (0.57) | REV1MAPTUSP2RECQLHSD17B10 | |
| SCHEMBL3012956 | 0.84 | MAPT (0.51) | REV1MAPTUSP2RECQLHSD17B10 | |
| SCHEMBL3008929 | 0.84 | REV1 (0.55) | REV1MAPTUSP2RECQLHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188272-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV Remynd (BE) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009019295-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2009-02-12 | — | — | WO | disclosed |