Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3005087 | 0.96 | MAPT (0.46) | MAPTUSP2RECQLHSD17B10HTR1A | |
| SCHEMBL2997804 | 0.93 | GBA1 (0.45) | MAPTALDH1A1LMNAPOLBGBA1 | |
| SCHEMBL3015321 | 0.88 | ALDH1A1 (0.49) | MAPTUSP2RECQLHSD17B10HTR1A | |
| SCHEMBL3006243 | 0.87 | MEN1 (0.52) | MAPTUSP2RECQLHSD17B10ALDH1A1 | |
| SCHEMBL3013460 | 0.86 | SMN1; SMN2 (0.44) | MAPTUSP2RECQLHSD17B10ALDH1A1 | |
| SCHEMBL3005294 | 0.85 | TP53 (0.56) | MAPTUSP2RECQLHSD17B10ALDH1A1 | |
| SCHEMBL3013485 | 0.85 | MAPT (0.58) | MAPTUSP2RECQLHSD17B10ALDH1A1 | |
| SCHEMBL3015412 | 0.85 | MEN1 (0.54) | MAPTUSP2RECQLHSD17B10HTR1A | |
| SCHEMBL3017323 | 0.85 | RECQL (0.48) | MAPTUSP2RECQLHSD17B10ALDH1A1 | |
| SCHEMBL3014224 | 0.85 | MAPT (0.48) | MAPTUSP2RECQLHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188272-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV Remynd (BE) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009019295-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2009-02-12 | — | — | WO | disclosed |