Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3013091 | 0.97 | GAA (0.51) | MAPK1GAAALDH1A1MAPTRECQL | |
| SCHEMBL3011626 | 0.97 | GAA (0.51) | MAPK1GAAALDH1A1MAPTRECQL | |
| SCHEMBL3011303 | 0.92 | ALDH1A1 (0.55) | MAPK1GAAALDH1A1MAPTRECQL | |
| SCHEMBL3649255 | 0.90 | GAA (0.48) | MAPK1GAAALDH1A1MAPTRECQL | |
| SCHEMBL3652435 | 0.90 | MAPK1 (0.52) | MAPK1GAAALDH1A1MAPTRECQL | |
| SCHEMBL3001973 | 0.90 | GAA (0.51) | MAPK1GAAALDH1A1MAPTRECQL | |
| SCHEMBL3010047 | 0.90 | GAA (0.51) | MAPK1GAAALDH1A1MAPTRECQL | |
| SCHEMBL2998195 | 0.90 | GAA (0.51) | MAPK1GAAALDH1A1MAPTRECQL | |
| SCHEMBL3002250 | 0.90 | ALDH1A1 (0.55) | MAPK1GAAALDH1A1MAPTRECQL | |
| SCHEMBL3015767 | 0.89 | GAA (0.50) | GAAALDH1A1MAPTRECQLKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188272-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV Remynd (BE) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009019295-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2009-02-12 | — | — | WO | disclosed |