Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
| ▸ | SI | P14410 | 1/20 | 0.34 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1155341 | 1.00 | CYP2D6 (0.49) | CYP2D6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL6154559 | 0.91 | CYP2D6 (0.50) | CYP2D6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL28243 | 0.84 | TSHR (0.50) | CA12CA14TSHRGAAHSD17B10 | |
| SCHEMBL3911629 | 0.83 | SLC22A6 (0.54) | CYP2D6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL3914001 | 0.83 | SLC22A6 (0.54) | CYP2D6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL25787717 | 0.83 | CYP2D6 (0.45) | CYP2D6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL12861679 | 0.83 | CYP2D6 (0.49) | CYP2D6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL3911627 | 0.83 | SLC22A6 (0.54) | CYP2D6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL19821805 | 0.82 | CYP2D6 (0.35) | CYP2D6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL28825762 | 0.82 | CYP2D6 (0.44) | CYP2D6HDAC3HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2178846-A1 | ROSUVASTATIN INTERMEDIATES AND THEIR PREPARATION | Teva Pharmaceutical Industries Ltd. (IL) | 2010-04-28 | — | — | EP | disclosed |
| EP-2062903-A1 | Statin intermediates and process for the preparation of statins | Teva Pharmaceutical Industries Ltd. (IL) | 2009-05-27 | — | — | EP | disclosed |
| US-20090076292-A1 | Rosuvastatin intermediates and process for the preparation of rosuvastatin | TEVA PHARMACEUTICAL INDUSTRIES LTD. | 2009-03-19 | — | — | US | disclosed |
| US-20090069563-A1 | Rosuvastatin intermediates and their preparation | TEVA PHARMACEUTICALS USA, INC. | 2009-03-12 | — | — | US | disclosed |
| EP-2032587-A2 | ROSUVASTATIN INTERMEDIATES AND PROCESS FOR THE PREPARATION OF ROSUVASTATIN | Teva Pharmaceutical Industries Ltd. (IL) | 2009-03-11 | — | — | EP | disclosed |
| WO-2009009152-A1 | ROSUVASTATIN INTERMEDIATES AND THEIR PREPARATION | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2009-01-15 | — | — | WO | disclosed |
| WO-2008130678-A2 | ROSUVASTATIN INTERMEDIATES AND PROCESS FOR THE PREPARATION OF ROSUVASTATIN | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2008-10-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090076292-A1 | Rosuvastatin intermediates and process for the preparation of rosuvastatin | HMGCR, PCSK9, CYP4A11 | CYP2D6 524/4885HDAC3 581/4885HDAC1 956/4885 |
| US-20090069563-A1 | Rosuvastatin intermediates and their preparation | HMGCR, PCSK9, PCSK7 | CYP2D6 577/4885HDAC3 475/4885HDAC1 869/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.