Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 9/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | GBA1 | P04062 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3011478 | 0.95 | MAPT (0.55) | HSD11B1USP2MAPTRECQLHSD17B10 | |
| SCHEMBL3023448 | 0.93 | HSD11B1 (0.59) | HSD11B1USP2MAPTRECQLHSD17B10 | |
| SCHEMBL3002316 | 0.87 | MAPT (0.58) | HSD11B1USP2MAPTRECQLHSD17B10 | |
| SCHEMBL3007848 | 0.85 | HSD11B1 (0.54) | HSD11B1USP2MAPTRECQLHSD17B10 | |
| SCHEMBL3003753 | 0.85 | MAPT (0.63) | HSD11B1USP2MAPTRECQLHSD17B10 | |
| SCHEMBL3016396 | 0.85 | MAPT (0.68) | USP2MAPTRECQLHSD17B10ALDH1A1 | |
| SCHEMBL3012414 | 0.85 | MAPT (0.60) | HSD11B1USP2MAPTRECQLHSD17B10 | |
| SCHEMBL3002381 | 0.84 | TSHR (0.60) | HSD11B1USP2MAPTRECQLHSD17B10 | |
| SCHEMBL3005656 | 0.84 | MAPT (0.57) | USP2MAPTRECQLHSD17B10ALDH1A1 | |
| SCHEMBL3010513 | 0.84 | USP2 (0.57) | USP2MAPTRECQLHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188272-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV Remynd (BE) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009019295-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2009-02-12 | — | — | WO | disclosed |