Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 9/20 | 0.92 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.92 |
| ▸ | NR3C1 | P04150 | 7/20 | 0.92 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.92 |
| ▸ | LMNA | P02545 | 3/20 | 0.92 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.92 |
| ▸ | BLM | P54132 | 2/20 | 0.92 |
| ▸ | MAPT | P10636 | 1/20 | 0.92 |
| ▸ | GAA | P10253 | 1/20 | 0.92 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.92 |
| ▸ | PGR | P06401 | 4/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.71 |
| ▸ | AR | P10275 | 3/20 | 0.71 |
| ▸ | TSHR | P16473 | 2/20 | 0.71 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.71 |
| ▸ | APEX1 | P27695 | 1/20 | 0.71 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Beclomethasone SCHEMBL28012658 | 1.00 | HIF1A (0.92) | HIF1ACYP3A4NR3C1NFKB1LMNA | |
| Beclomethasone SCHEMBL102221 | 1.00 | HIF1A (0.92) | HIF1ACYP3A4NR3C1NFKB1LMNA | |
| Beclomethasone SCHEMBL7330 | 1.00 | HIF1A (0.92) | HIF1ACYP3A4NR3C1NFKB1LMNA | |
| Beclomethasone SCHEMBL28350204 | 0.99 | HIF1A (0.90) | HIF1ACYP3A4NR3C1NFKB1LMNA | |
| Beclomethasone SCHEMBL74652 | 0.99 | HIF1A (0.90) | HIF1ACYP3A4NR3C1NFKB1LMNA | |
| Beclomethasone SCHEMBL3886336 | 0.99 | HIF1A (0.90) | HIF1ACYP3A4NR3C1NFKB1LMNA | |
| Beclomethasone SCHEMBL7806488 | 0.97 | HIF1A (0.86) | HIF1ACYP3A4NR3C1NFKB1LMNA | |
| Beclomethasone SCHEMBL10555672 | 0.97 | HIF1A (0.86) | HIF1ACYP3A4NR3C1NFKB1LMNA | |
| Beclomethasone SCHEMBL5486743 | 0.96 | HIF1A (1.00) | HIF1ACYP3A4NR3C1NFKB1LMNA | |
| Beclomethasone SCHEMBL18762039 | 0.96 | HIF1A (1.00) | HIF1ACYP3A4NR3C1NFKB1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200581-A2 | STEROID CONTAINING OPHTHALMIC DRUG DELIVERY SYSTEMS | ALLERGAN, INC. (US) | 2010-06-30 | — | — | EP | claimed |
| WO-2009039262-A2 | STEROID CONTAINING OPHTHALMIC DRUG DELIVERY SYSTEMS | ALLERGAN, INC. (US) | 2009-03-26 | — | — | WO | claimed |
| US-20090082321-A1 | STEROID CONTAINING DRUG DELIVERY SYSTEMS | ALLERGAN, INC. (US) | 2009-03-26 | — | — | US | claimed |
| US-8859550-B2 | Heterocyclic inhibitors of histamine receptors for the treatment of disease | KALYPSYS, INC. (US) | 2014-10-14 | — | — | US | disclosed |
| US-20130245001-A1 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2013-09-19 | — | — | US | disclosed |
| WO-2013039785-A2 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2013-03-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090082321-A1 | STEROID CONTAINING DRUG DELIVERY SYSTEMS | HSD17B2, HSD17B3, HSD17B7 | HIF1A 2544/4885CYP3A4 1549/4885NR3C1 5/4885 |
| US-20130245001-A1 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | HRH4, HRH2, HRH3 | HIF1A 993/4885CYP3A4 775/4885NR3C1 396/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.