Sugi Predict

Sugi Predict / Targets / HSD17B7

HSD17B7

3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 · P56937 · HSD17B7 on Sugi Atlas →

345 patent compounds predicted against HSD17B7, 312 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL9066257 SCHEMBL9066257 1.00 2/20
SCHEMBL9066263 SCHEMBL9066263 0.98 2/20
SCHEMBL9065998 SCHEMBL9065998 0.93 2/20
SCHEMBL9067243 SCHEMBL9067243 0.85 2/20
SCHEMBL9270109 SCHEMBL9270109 0.85 2/20
SCHEMBL9065996 SCHEMBL9065996 0.76 2/20
SCHEMBL9066601 SCHEMBL9066601 0.74 2/20
SCHEMBL8722430 SCHEMBL8722430 0.70 2/20
SCHEMBL8722432 SCHEMBL8722432 0.70 2/20
SCHEMBL8996735 SCHEMBL8996735 0.70 2/20
SCHEMBL9066463 SCHEMBL9066463 0.69 2/20
SCHEMBL9066669 SCHEMBL9066669 0.68 2/20
SCHEMBL9286706 SCHEMBL9286706 0.67 2/20
SCHEMBL9066132 SCHEMBL9066132 0.67 2/20
SCHEMBL9273771 SCHEMBL9273771 0.67 2/20
SCHEMBL8065477 SCHEMBL8065477 0.66 2/20
SCHEMBL8065480 SCHEMBL8065480 0.66 2/20
SCHEMBL8078905 SCHEMBL8078905 0.66 2/20
SCHEMBL8078906 SCHEMBL8078906 0.66 2/20
SCHEMBL8080711 SCHEMBL8080711 0.66 2/20

Clinical trials — most relevant to HSD17B7 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Congenital Adrenal Hyperplasia Once Daily Hydrocortisone Treatment PHASE4RECRUITING
Orteronel Maintenance Therapy in Patients With mCRPC Previously Treated With Novel Hormonal Agents PHASE3WITHDRAWN
Theca Cell Function in Adolescents With Polycystic Ovary Syndrome (PCOS) PHASE3COMPLETED
Orteronel Maintenance Therapy in Patients With Metastatic Castration Resistant Prostate Cancer and Non-progressive Disease After First-line Docetaxel Therapy PHASE3COMPLETED
Androgen Reduction in Congenital Adrenal Hyperplasia PHASE2WITHDRAWN
Activity of Abiraterone Acetate in the Management of Cushing's Syndrome in Patients With Adrenocortical Carcinoma PHASE2UNKNOWN
AMG 386 and Abiraterone for Advanced Prostate Cancer PHASE2COMPLETED
A Phase 2 Study to Evaluate the Effects of ASP5541 in Participants With Prostate Cancer PHASE2RECRUITING
Comparison of Two Forms of Hydrocortisone in Patients With Congenital Adrenal Hyperplasia PHASE1/PHASE2COMPLETED
A Study Examining Doses of Abiraterone Acetate in Adult Women With 21-Hydroxylase Deficiency PHASE1COMPLETED
A Study to Evaluate the Safety and Drug Levels of ASP5541 in Chinese Participants With Prostate Cancer PHASE1RECRUITING
Biomarkers in Bone Marrow and Blood Samples From Patients With Prostate Cancer Treated With Ketoconazole nanWITHDRAWN
Polycystic Ovary Syndrome in Type 1 Diabetes nanNOT_YET_RECRUITING
Mutation Analysis of 17βhydroxysteroid Dehydrogenase 3 Deficiency nanUNKNOWN
Determining the Long-Term Effects of Prenatal Dexamethasone Treatment in Children With 21-Hydroxylase Deficiency and Their Mothers nanUNKNOWN
Mutation Analysis of 17α-Hydroxylase nanUNKNOWN
Study of Smith-Lemli-Opitz Syndrome nanCOMPLETED
Pattern of Gene Expression in Adipose Tissue From Patients With Cushing Syndrome nanCOMPLETED
Linear Growth of Children With Congenital Adrenal Hyperplasia nanUNKNOWN
Final Height in Patients With CAH nanUNKNOWN
Impact of 11-oxygenated Androgens on Metabolic Dysfunction of Women With Polycystic Ovary Syndrome nanUNKNOWN
Exercise Capacity, Physical Fitness, and Physical Activity Levels in Children With CAH nanCOMPLETED
Evaluating a Personalised Online Program With Human Support for Women With Depression and Its Impact on Mental Health and Biological Changes nanNOT_YET_RECRUITING
Examining Genetic Differences Among People With 21-Hydroxylase Deficiency nanCOMPLETED
Ovarian Morphology and Theca Cell Androgen Production in Women With Polycystic Ovary Syndrome (PCOS) nanCOMPLETED
Gene Polymorphisms Influencing Steroid Synthesis and Action nanWITHDRAWN
Furocyst - Poly Cystic Ovary Syndrome Study nanCOMPLETED
Adrenal Function in GHD Children nanCOMPLETED
Meal Timing on Glucose Metabolism and Hyperandrogenism in Lean Women With Polycystic Ovary Syndrome nanUNKNOWN
A Prospective Observational Study of Biomarkers for a Personalised IVF Treatment nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a HSD17B7 binder may also engage these)

ProteinNameSimilarity
Q62904 — 0.999 Q62904 →
O88736 — 0.996 O88736 →
Q64421 — 0.974 Q64421 →
P27364 — 0.972 P27364 →
P24815 — 0.971 P24815 →
O35296 — 0.971 O35296 →
O46516 — 0.971 O46516 →
Q9Y394 — 0.970 Q9Y394 →
HSD3B1 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 0.969 landscape →
Q61767 — 0.969 Q61767 →
HSD3B2 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 0.968 landscape →
Q60555 — 0.967 Q60555 →
A0PJE2 — 0.966 A0PJE2 →
Q9D665 — 0.966 Q9D665 →
Q61694 — 0.966 Q61694 →
P22071 — 0.965 P22071 →
Q5RJY4 — 0.965 Q5RJY4 →
O35469 — 0.964 O35469 →
Q5R6U1 — 0.964 Q5R6U1 →
P26150 — 0.964 P26150 →
Q99J47 — 0.963 Q99J47 →
Q9N119 — 0.962 Q9N119 →
P27365 — 0.962 P27365 →
P22072 — 0.962 P22072 →
Q1LZ86 — 0.961 Q1LZ86 →
Q5IH13 — 0.961 Q5IH13 →
Q7SY73 — 0.961 Q7SY73 →
Q9CXR1 — 0.961 Q9CXR1 →
Q8CCT7 — 0.960 Q8CCT7 →
Q6GLL2 — 0.960 Q6GLL2 →