Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3010350 | 0.95 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2L3MBTL1MAPTUSP2 | |
| SCHEMBL3014606 | 0.94 | ALDH1A1 (0.63) | ALDH1A1SMN1; SMN2L3MBTL1MAPTUSP2 | |
| SCHEMBL3008637 | 0.89 | ALDH1A1 (0.61) | ALDH1A1SMN1; SMN2L3MBTL1MAPTUSP2 | |
| SCHEMBL3010340 | 0.87 | SMN1; SMN2 (0.61) | ALDH1A1SMN1; SMN2L3MBTL1MAPTUSP2 | |
| SCHEMBL3009477 | 0.85 | ALDH1A1 (0.66) | ALDH1A1SMN1; SMN2L3MBTL1MAPTUSP2 | |
| SCHEMBL3003612 | 0.85 | MAPT (0.72) | ALDH1A1SMN1; SMN2L3MBTL1MAPTUSP2 | |
| SCHEMBL3002815 | 0.84 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2L3MBTL1MAPTUSP2 | |
| SCHEMBL3013950 | 0.84 | MAPT (0.67) | ALDH1A1SMN1; SMN2L3MBTL1MAPTUSP2 | |
| SCHEMBL3013237 | 0.84 | SMN1; SMN2 (0.80) | ALDH1A1SMN1; SMN2L3MBTL1MAPTUSP2 | |
| SCHEMBL3014982 | 0.84 | SMN1; SMN2 (0.69) | ALDH1A1SMN1; SMN2L3MBTL1MAPTUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188272-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV Remynd (BE) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009019295-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2009-02-12 | — | — | WO | disclosed |