Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 4/20 | 0.41 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6039509 | 0.83 | NSD3 (0.43) | BRD4MAPK14GABRA1GABRG2GABRB3 | |
| SCHEMBL6039495 | 0.79 | CYP1A2 (0.49) | HTR3ABRD4NISCHMAPK14 | |
| Trifluoroacetic Acid SCHEMBL16827760 | 0.74 | NSD3 (0.39) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL3647759 | 0.73 | PRKCI (0.44) | NR1H4SLC6A2SLC6A4SLC6A3BRD4 | |
| SCHEMBL3646647 | 0.72 | NR1H4 (0.41) | NR1H4SLC6A2SLC6A4HTR3AKCNH2 | |
| SCHEMBL3651945 | 0.72 | NR1H4 (0.48) | NR1H4SLC6A2SLC6A4HTR3AKCNH2 | |
| SCHEMBL3652136 | 0.72 | PRKCI (0.43) | NR1H4BRD4MAPK14MAPK9MAPK13 | |
| SCHEMBL3644182 | 0.72 | NR1H4 (0.43) | NR1H4SLC6A2SLC6A4HTR3AKCNH2 | |
| SCHEMBL3696040 | 0.71 | PRKDC (0.37) | NR1H4SLC6A2SLC6A4HTR3AKCNH2 | |
| SCHEMBL3698976 | 0.71 | NR1H4 (0.36) | NR1H4SLC6A2SLC6A4HTR3AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185556-A1 | IMIDAZOPYRIDINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM | Wyeth a Corporation of the State of Delaware (US) | 2010-05-19 | — | — | EP | disclosed |
| WO-2009029609-A1 | IMIDAZOPYRIDINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM | WYETH (US) | 2009-03-05 | — | — | WO | disclosed |