Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 3/20 | 0.48 |
| ▸ | EGFR | P00533 | 3/20 | 0.48 |
| ▸ | SRC | P12931 | 3/20 | 0.48 |
| ▸ | ABL2 | P42684 | 3/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | PLAT | P00750 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28695130 | 0.88 | ABL1 (0.51) | ABL1EGFRSRCABL2KDM4E | |
| SCHEMBL6039509 | 0.80 | NSD3 (0.43) | TDP1EGFRSRCMAPK14BRD4 | |
| SCHEMBL3651007 | 0.79 | NR1H4 (0.47) | MAPK14NISCHBRD4HTR3A | |
| SCHEMBL3959958 | 0.73 | HTR2C (0.48) | CYP1A2TDP1ABL1EGFRSRC | |
| Hydrochloric Acid SCHEMBL3250146 | 0.73 | HTR2C (0.48) | CYP1A2TDP1ABL1EGFRSRC | |
| SCHEMBL5362756 | 0.73 | DYRK1A (0.56) | CYP1A2TDP1CYP2C19CYP3A4HSD17B10 | |
| SCHEMBL28851921 | 0.72 | DYRK1A (0.54) | CYP1A2TDP1CYP2C19CYP3A4HSD17B10 | |
| Trifluoroacetic Acid SCHEMBL16827760 | 0.72 | NSD3 (0.39) | MAPK14LMNA | |
| SCHEMBL29664258 | 0.71 | MAP4K4 (0.41) | SRCHSD17B10KDM4EALDH1A1MAPT | |
| SCHEMBL8098925 | 0.71 | SRC (0.89) | ABL1EGFRSRCABL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664042-A1 | IMIDAZO 1,5-a PYRIDINE OR IMIDAZO 1,5-a PIPERIDINE DERIVATIVES AND THEIR USE FOR THE PREPARATION OF MEDICAMENT AGAINST 5-HT2A RECEPTOR-RELATED DISORDERS | Galapagos N.V. (BE) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005021545-A1 | IMIDAZO[1,5-a]PYRIDINE OR IMIDAZO[1,5-a]PIPERIDINE DERIVATIVES AND THEIR USE FOR THE PREPARATION OF MEDICAMENT AGAINST 5-HT2A RECEPTOR-RELATED DISORDERS | GALAPAGOS NV (BE) | 2005-03-10 | — | — | WO | disclosed |