Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pheniramine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 5/20 | 0.78 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.97 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.97 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.97 |
| ▸ | SCN1A | P35498 | 3/20 | 0.97 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.97 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.97 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.78 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.78 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.78 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.78 |
| ▸ | HTR2A | P28223 | 4/20 | 0.78 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.78 |
| ▸ | LMNA | P02545 | 3/20 | 0.78 |
| ▸ | TSHR | P16473 | 3/20 | 0.78 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.78 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.78 |
| ▸ | THPO | P40225 | 2/20 | 0.78 |
| ▸ | DRD1 | P21728 | 2/20 | 0.78 |
| ▸ | HTR2C | P28335 | 2/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pheniramine SCHEMBL126153 | 0.98 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4SCN1ASCN2A | |
| Pheniramine SCHEMBL30182646 | 0.98 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4SCN1ASCN2A | |
| Pheniramine SCHEMBL4796 | 0.98 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4SCN1ASCN2A | |
| Pheniramine SCHEMBL48720 | 0.98 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4SCN1ASCN2A | |
| Pheniramine SCHEMBL18240052 | 0.97 | CHRM2 (0.97) | CHRM2SLC6A2SLC6A4SCN1ASCN2A | |
| Dexchlorpheniramine SCHEMBL31134035 | 0.90 | CHRM2 (0.97) | CHRM2SLC6A2SLC6A4SCN1ASCN2A | |
| Chlorpheniramine SCHEMBL506017 | 0.90 | CHRM2 (0.97) | CHRM2SLC6A2SLC6A4SCN1ASCN2A | |
| Chlorpheniramine SCHEMBL506016 | 0.90 | CHRM2 (0.97) | CHRM2SLC6A2SLC6A4SCN1ASCN2A | |
| Chlorpheniramine SCHEMBL10622596 | 0.90 | CHRM2 (0.97) | CHRM2SLC6A2SLC6A4SCN1ASCN2A | |
| Dexbrompheniramine SCHEMBL28086608 | 0.90 | CHRM2 (0.97) | CHRM2SLC6A2SLC6A4SCN1ASCN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115003279-A | Prodrug compositions and methods of treatment | 阿奎斯蒂弗医疗股份有限公司 | 2022-09-02 | — | — | CN | disclosed |
| CN-114466658-A | Orally delivered therapeutic compositions and uses thereof | 沈海发 | 2022-05-10 | — | — | CN | disclosed |
| EP-1804761-B1 | COMPOSITIONS AND METHODS FOR TREATMENT OF SKIN DISCOLORATION | EVERA LAB LLC (US) | 2015-09-02 | — | — | EP | disclosed |
| EP-2485691-A1 | OPHTHALMIC DRUG DELIVERY | Corinthian Ophthalmic, Inc. (US) | 2012-08-15 | — | — | EP | disclosed |
| WO-2012009696-A2 | OPHTHALMIC DRUG DELIVERY | CORINTHIAN OPHTHALMIC, INC. (US) | 2012-01-19 | — | — | WO | disclosed |
| EP-1804761-A4 | COMPOSITIONS AND METHODS FOR TREATMENT OF SKIN DISCOLORATION | EVERA LAB LLC (US) | 2008-09-17 | — | — | EP | disclosed |
| EP-1804761-A2 | COMPOSITIONS AND METHODS FOR TREATMENT OF SKIN DISCOLORATION | Boxrud, Cynthia A. (US) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006031555-A2 | COMPOSITIONS AND METHODS FOR TREATMENT OF SKIN DISCOLORATION | BOXRUD, CYNTHIA, A. (US) | 2006-03-23 | — | — | WO | disclosed |
| CN-1126441-A | Amplification of vitamin B12 absorption System Using polymers | BIOTECH AUSTRALIA PTY LTD (AU) | 1996-07-10 | — | — | CN | disclosed |