Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 20/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 13/20 | 0.59 |
| ▸ | AKT2 | P31751 | 11/20 | 0.58 |
| ▸ | AKT3 | Q9Y243 | 11/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.57 |
| ▸ | LATS1 | O95835 | 2/20 | 0.57 |
| ▸ | PRKCB | P05771 | 2/20 | 0.57 |
| ▸ | RET | P07949 | 2/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.57 |
| ▸ | PRKCA | P17252 | 2/20 | 0.57 |
| ▸ | PRKACA | P17612 | 2/20 | 0.57 |
| ▸ | PRKACB | P22694 | 2/20 | 0.57 |
| ▸ | GRK2 | P25098 | 2/20 | 0.57 |
| ▸ | CLK1 | P49759 | 2/20 | 0.57 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.57 |
| ▸ | LIMK2 | P53671 | 2/20 | 0.57 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.57 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3650885 | 0.88 | AKT1 (0.57) | AKT1ROCK2AKT2AKT3KCNH2 | |
| SCHEMBL392547 | 0.85 | AKT1 (0.78) | AKT1ROCK2AKT2AKT3KCNH2 | |
| SCHEMBL20544757 | 0.85 | AKT1 (0.78) | AKT1ROCK2AKT2AKT3KCNH2 | |
| SCHEMBL20544952 | 0.85 | AKT1 (0.80) | AKT1ROCK2AKT2AKT3KCNH2 | |
| SCHEMBL20545432 | 0.84 | AKT1 (0.79) | AKT1ROCK2AKT2AKT3KCNH2 | |
| SCHEMBL20544918 | 0.83 | AKT1 (0.79) | AKT1ROCK2AKT2AKT3KCNH2 | |
| SCHEMBL15809880 | 0.83 | AKT1 (0.79) | AKT1ROCK2AKT2AKT3KCNH2 | |
| SCHEMBL20544988 | 0.83 | AKT1 (0.80) | AKT1ROCK2AKT2AKT3KCNH2 | |
| SCHEMBL28803704 | 0.83 | AKT1 (0.79) | AKT1ROCK2AKT2AKT3KCNH2 | |
| SCHEMBL20545097 | 0.82 | AKT1 (0.79) | AKT1ROCK2AKT2AKT3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2201012-A1 | PYRROLO [2, 3 -D] PYRIMIDIN DERIVATIVES AS PROTEIN KINASE B INHIBITORS | AstraZeneca AB (SE) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009047563-A1 | PYRROLO [2, 3 -D] PYRIMIDIN DERIVATIVES AS PROTEIN KINASE B INHIBITORS | ASTRAZENECA AB (SE) | 2009-04-16 | — | — | WO | disclosed |