Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3013128 | 0.98 | KDM4E (0.44) | KDM4ENPSR1TSHRALDH1A1KMT2A | |
| SCHEMBL3020021 | 0.94 | NPSR1 (0.47) | KDM4ENPSR1TSHRALDH1A1KMT2A | |
| SCHEMBL3017975 | 0.92 | KDM4E (0.41) | KDM4ENPSR1TSHRALDH1A1KMT2A | |
| SCHEMBL3008378 | 0.89 | EPHX2 (0.47) | KDM4ENPSR1TSHRALDH1A1KMT2A | |
| SCHEMBL3013725 | 0.89 | ALDH1A1 (0.40) | KDM4ENPSR1TSHRALDH1A1KMT2A | |
| SCHEMBL3014339 | 0.88 | KMT2A (0.43) | KDM4ENPSR1ALDH1A1KMT2AMAPT | |
| SCHEMBL3002536 | 0.86 | EPHX2 (0.48) | KDM4ENPSR1TSHRALDH1A1KMT2A | |
| SCHEMBL3004672 | 0.86 | NPSR1 (0.43) | KDM4ENPSR1TSHRALDH1A1KMT2A | |
| SCHEMBL2999629 | 0.86 | NPSR1 (0.45) | KDM4ENPSR1TSHRALDH1A1KMT2A | |
| SCHEMBL3022608 | 0.86 | KMT2A (0.45) | KDM4ENPSR1TSHRALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188272-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV Remynd (BE) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009019295-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2009-02-12 | — | — | WO | disclosed |