Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ACLY | P53396 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3006868 | 0.95 | MAPT (0.47) | MAPTLMNARECQLTSHRUSP2 | |
| SCHEMBL3009247 | 0.91 | ALDH1A1 (0.44) | MAPTLMNARECQLTSHRUSP2 | |
| SCHEMBL3648044 | 0.89 | MAPT (0.42) | MAPTLMNARECQLTSHRUSP2 | |
| SCHEMBL3653907 | 0.88 | KMT2A (0.48) | MAPTLMNARECQLTSHRUSP2 | |
| SCHEMBL3004272 | 0.88 | MAPT (0.47) | MAPTLMNARECQLTSHRUSP2 | |
| SCHEMBL3010103 | 0.88 | MAPT (0.47) | MAPTLMNARECQLTSHRUSP2 | |
| SCHEMBL3016382 | 0.87 | ALDH1A1 (0.43) | MAPTLMNARECQLTSHRUSP2 | |
| SCHEMBL3020101 | 0.87 | ALDH1A1 (0.43) | MAPTLMNARECQLTSHRUSP2 | |
| SCHEMBL3002468 | 0.86 | MAPT (0.48) | MAPTLMNARECQLTSHRUSP2 | |
| SCHEMBL3012765 | 0.86 | ALDH1A1 (0.52) | MAPTLMNARECQLTSHRUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188272-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV Remynd (BE) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009019295-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2009-02-12 | — | — | WO | disclosed |