Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL166445 | 0.94 | USP2 (0.42) | USP2SMN1; SMN2EPHX1MAPTKDM4E | |
| SCHEMBL173426 | 0.86 | HPGD (0.44) | USP2SMN1; SMN2EPHX1MAPTKDM4E | |
| SCHEMBL171462 | 0.84 | EPHX1 (0.50) | USP2SMN1; SMN2EPHX1MAPTKDM4E | |
| SCHEMBL31028 | 0.83 | USP2 (0.56) | USP2SMN1; SMN2EPHX1MAPTKDM4E | |
| SCHEMBL27669441 | 0.83 | USP2 (0.56) | USP2SMN1; SMN2EPHX1MAPTKDM4E | |
| Ammonia Solution, Strong SCHEMBL27841683 | 0.82 | USP2 (0.55) | USP2SMN1; SMN2EPHX1MAPTKDM4E | |
| Iodomethane SCHEMBL15848230 | 0.80 | USP2 (0.53) | USP2SMN1; SMN2EPHX1MAPTKDM4E | |
| Ethylene SCHEMBL3832936 | 0.80 | USP2 (0.53) | USP2SMN1; SMN2EPHX1MAPTKDM4E | |
| SCHEMBL26093324 | 0.79 | NR1H2 (0.43) | USP2SMN1; SMN2EPHX1MAPTKDM4E | |
| SCHEMBL12908934 | 0.78 | USP2 (0.44) | USP2SMN1; SMN2EPHX1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2197552-A2 | NOVEL TETRAHYDROFUSEDPYRIDINES AS HISTONE DEACETYLASE INHIBITORS | 4SC AG (DE) | 2010-06-23 | — | — | EP | disclosed |
| WO-2009037001-A2 | NOVEL TETRAHYDROFUSEDPYRIDINES AS HISTONE DEACETYLASE INHIBITORS | 4SC AG (DE) | 2009-03-26 | — | — | WO | disclosed |