Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 11/20 | 0.63 |
| ▸ | AKT1 | P31749 | 4/20 | 0.49 |
| ▸ | ACVR1 | Q04771 | 5/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
| ▸ | MTOR | P42345 | 2/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.41 |
| ▸ | GAK | O14976 | 1/20 | 0.41 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.41 |
| ▸ | STK10 | O94804 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.41 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL730195 | 0.82 | PIK3CA (0.84) | PIK3CAAKT1ACVR1PIK3CDPIK3CB | |
| SCHEMBL732362 | 0.81 | PIK3CA (0.60) | PIK3CAAKT1ACVR1MTORMAPK10 | |
| SCHEMBL730188 | 0.80 | PIK3CA (0.87) | PIK3CAAKT1ACVR1PIK3CDPIK3CB | |
| SCHEMBL730355 | 0.80 | PIK3CA (0.70) | PIK3CAAKT1ACVR1PIK3CDPIK3CB | |
| SCHEMBL740069 | 0.77 | PIK3CA (0.67) | PIK3CAAKT1ACVR1PIK3CDPIK3CB | |
| SCHEMBL729449 | 0.77 | PIK3CA (1.00) | PIK3CAAKT1ACVR1PIK3CDPIK3CB | |
| SCHEMBL732188 | 0.77 | PIK3CA (0.71) | PIK3CAAKT1ACVR1PIK3CDPIK3CB | |
| SCHEMBL10156122 | 0.77 | PIK3CA (0.71) | PIK3CAAKT1PIK3CDPIK3CBMTOR | |
| SCHEMBL20292912 | 0.76 | DYRK1B (0.70) | PIK3CAAKT1PIM1DYRK1ADYRK1B | |
| Ammonia Solution, Strong SCHEMBL28021055 | 0.75 | PIK3CA (0.61) | PIK3CAAKT1ACVR1DYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2192902-A1 | QUINOLINE DERIVATIVES AS P13 KINASE INHIBITORS | GlaxoSmithKline LLC (US) | 2010-06-09 | — | — | EP | disclosed |
| WO-2008144464-A1 | QUINOLINE DERIVATIVES AS P13 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-11-27 | — | — | WO | disclosed |
| WO-2008144463-A1 | QUINOLINE DERIVATIVES AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-11-27 | — | — | WO | disclosed |