Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | KDM1A | O60341 | 2/20 | 0.51 |
| ▸ | AR | P10275 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | GBA1 | P04062 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3011261 | 0.94 | AR (0.57) | ALDH1A1SMN1; SMN2L3MBTL1ARMAPT | |
| SCHEMBL3002525 | 0.93 | SMN1; SMN2 (0.59) | ALDH1A1SMN1; SMN2L3MBTL1KDM1AAR | |
| SCHEMBL3016680 | 0.89 | SMN1; SMN2 (0.59) | ALDH1A1SMN1; SMN2L3MBTL1MAPTUSP2 | |
| SCHEMBL3011390 | 0.87 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2L3MBTL1KDM1AAR | |
| SCHEMBL3014880 | 0.87 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2L3MBTL1KDM1AAR | |
| SCHEMBL3004669 | 0.87 | MAPT (0.60) | ALDH1A1SMN1; SMN2L3MBTL1KDM1AMAPT | |
| SCHEMBL3018379 | 0.87 | HTT (0.62) | ALDH1A1SMN1; SMN2L3MBTL1ARMAPT | |
| SCHEMBL3010287 | 0.86 | HTT (0.53) | ALDH1A1SMN1; SMN2L3MBTL1KDM1AAR | |
| SCHEMBL3015607 | 0.86 | KDM1A (0.57) | ALDH1A1SMN1; SMN2L3MBTL1KDM1AMAPT | |
| SCHEMBL3015353 | 0.85 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2L3MBTL1KDM1AAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188272-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV Remynd (BE) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009019295-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2009-02-12 | — | — | WO | disclosed |