Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | KRAS | P01116 | 2/20 | 0.34 |
| ▸ | RORC | P51449 | 3/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | F13A1 | P00488 | 1/20 | 0.31 |
| ▸ | TGM2 | P21980 | 1/20 | 0.31 |
| ▸ | TGM1 | P22735 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL764140 | 0.78 | BACE1 (0.39) | RORCMEN1ALDH1A1KMT2A | |
| SCHEMBL12802260 | 0.77 | USP2 (0.40) | NR1H2EPHX2EPHX1USP2SMN1; SMN2 | |
| SCHEMBL344587 | 0.76 | NR1H2 (0.34) | NR1H2RORCUSP2SMN1; SMN2MEN1 | |
| SCHEMBL25185104 | 0.74 | NR1H2 (0.40) | NR1H2EPHX2RORCEPHX1USP2 | |
| SCHEMBL10150809 | 0.74 | USP2 (0.40) | NR1H2EPHX2RORCUSP2SMN1; SMN2 | |
| SCHEMBL21685747 | 0.73 | PDE4B (0.44) | RORCSMN1; SMN2MEN1KMT2AF13A1 | |
| SCHEMBL29217880 | 0.73 | USP2 (0.39) | NR1H2EPHX2EPHX1USP2SMN1; SMN2 | |
| SCHEMBL6143073 | 0.72 | NR1H2 (0.35) | NR1H2EPHX2KRASEPHX1USP2 | |
| SCHEMBL17107692 | 0.72 | EPHX1 (0.39) | NR1H2EPHX2RORCNAMPTEPHX1 | |
| SCHEMBL20474675 | 0.72 | PKM (0.36) | NR1H2EPHX2EPHX1USP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1565436-B1 | 3-AMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | INCYTE CORP (US) | 2012-04-25 | — | — | EP | disclosed |