SCHEMBL3654643

SCHEMBL3654643

CC(=O)CNc1ccc(Oc2ccc3cc(C(=O)O)n(C(=O)O)c3c2)nc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 1/20 0.38
PPARG P37231 3/20 0.37
CHRNA7 P36544 1/20 0.36
ALDH1A1 P00352 1/20 0.35
MAPT P10636 1/20 0.35
GFER P55789 1/20 0.35
PKM P14618 1/20 0.35
ROCK1 Q13464 2/20 0.35
GRN P28799 1/20 0.34
SORT1 Q99523 1/20 0.34
P2RX3 P56373 2/20 0.34
SCN9A Q15858 2/20 0.34
ADAMTS4 O75173 1/20 0.34
MMP1 P03956 1/20 0.34
MMP2 P08253 1/20 0.34
MMP13 P45452 1/20 0.34
MMP14 P50281 1/20 0.34
ADAMTS5 Q9UNA0 1/20 0.34
GAA P10253 1/20 0.33
HTT P42858 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3063818 0.80 MAPT (0.41) HRH3PPARGCHRNA7MAPTROCK1
SCHEMBL3057626 0.75 KDM4E (0.43) HRH3PPARGCHRNA7ALDH1A1GFER
SCHEMBL3064436 0.74 PPARG (0.40) PPARGCHRNA7GFERP2RX3SCN9A
SCHEMBL3056921 0.73 CCR9 (0.41) PPARGCHRNA7ALDH1A1MAPTGFER
SCHEMBL3066763 0.70 HRH3 (0.45) HRH3CHRNA7ALDH1A1MAPTROCK1
SCHEMBL3061248 0.69 ROCK1 (0.41) HRH3CHRNA7ALDH1A1MAPTGFER
SCHEMBL3064010 0.69 KDM4E (0.55) PPARGCHRNA7ALDH1A1MAPTGFER
SCHEMBL3063119 0.67 GAA (0.58) MAPTPKMGAA
SCHEMBL3062332 0.67 KCNQ3 (0.48) HRH3CHRNA7MAPTPKMGAA
SCHEMBL3705800 0.67 CHRNA7 (0.45) PPARGCHRNA7MAPTGFERPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2207773-B1 HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF OTSUKA PHARMA CO LTD (JP) 2012-07-11 EP disclosed
EP-2207773-A2 HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF Otsuka Pharmaceutical Co., Ltd. (JP) 2010-07-21 EP disclosed
WO-2009057811-A2 HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2009-05-07 WO disclosed