Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 13/20 | 0.60 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | HRH2 | P25021 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | HTR5A | P47898 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.48 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2217835 | 1.00 | CASR (0.60) | CASRHTR1AADRA2BADRA2CSLC6A2 | |
| SCHEMBL2218694 | 0.87 | PKM (0.46) | CASROPRM1LMNAHCRTR1HCRTR2 | |
| SCHEMBL2219196 | 0.87 | MEN1 (0.51) | CASRHTR1ASLC6A2OPRM1DRD3 | |
| SCHEMBL2219867 | 0.76 | CASR (0.59) | CASRHTR1AADRA2BADRA2CSLC6A2 | |
| SCHEMBL2218811 | 0.74 | CASR (0.49) | CASRHTR1AADRA2CSLC6A2HRH2 | |
| SCHEMBL27289914 | 0.74 | FGFR1 (0.49) | SIGMAR1CYP3A4CYP2D6 | |
| SCHEMBL14540134 | 0.73 | CASR (0.70) | CASRHTR1AADRA2BADRA2CSLC6A2 | |
| SCHEMBL15131119 | 0.73 | CASR (0.70) | CASRHTR1AADRA2BADRA2CSLC6A2 | |
| SCHEMBL3923152 | 0.73 | CASR (0.88) | CASRHTR1AADRA2BADRA2CSLC6A2 | |
| SCHEMBL2461168 | 0.72 | CASR (0.61) | CASRHTR1AADRA2BADRA2CSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212284-A2 | CALCIUM RECEPTOR MODULATING AGENTS | Amgen Inc. (US) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009051718-A2 | CALCIUM RECEPTOR MODULATING AGENTS | AMGEN INC. (US) | 2009-04-23 | — | — | WO | disclosed |