Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 18/20 | 0.49 |
| ▸ | AKT2 | P31751 | 9/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.46 |
| ▸ | AKT3 | Q9Y243 | 7/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3655526 | 0.94 | AKT1 (0.51) | AKT1AKT2ROCK2AKT3KCNH2 | |
| SCHEMBL3650884 | 0.93 | AKT1 (0.52) | AKT1AKT2ROCK2AKT3KCNH2 | |
| SCHEMBL3651764 | 0.92 | AKT1 (0.54) | AKT1AKT2ROCK2AKT3KCNH2 | |
| SCHEMBL3656537 | 0.92 | AKT1 (0.52) | AKT1AKT2ROCK2AKT3KCNH2 | |
| SCHEMBL3659051 | 0.90 | AKT1 (0.51) | AKT1AKT2ROCK2AKT3KCNH2 | |
| SCHEMBL391354 | 0.88 | AKT1 (0.51) | AKT1AKT2ROCK2AKT3KCNH2 | |
| SCHEMBL3651970 | 0.81 | AKT1 (0.55) | AKT1AKT2ROCK2AKT3KCNH2 | |
| SCHEMBL3654094 | 0.80 | AKT1 (0.52) | AKT1AKT2ROCK2AKT3KCNH2 | |
| SCHEMBL391814 | 0.80 | AKT1 (0.55) | AKT1AKT2ROCK2AKT3KCNH2 | |
| SCHEMBL390778 | 0.80 | AKT1 (0.73) | AKT1AKT2ROCK2AKT3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2201012-A1 | PYRROLO [2, 3 -D] PYRIMIDIN DERIVATIVES AS PROTEIN KINASE B INHIBITORS | AstraZeneca AB (SE) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009047563-A1 | PYRROLO [2, 3 -D] PYRIMIDIN DERIVATIVES AS PROTEIN KINASE B INHIBITORS | ASTRAZENECA AB (SE) | 2009-04-16 | — | — | WO | disclosed |