Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 17/20 | 0.92 |
| ▸ | ROCK1 | Q13464 | 12/20 | 0.92 |
| ▸ | GSK3B | P49841 | 7/20 | 0.92 |
| ▸ | CLK4 | Q9HAZ1 | 7/20 | 0.92 |
| ▸ | GSK3A | P49840 | 6/20 | 0.92 |
| ▸ | RPS6KA5 | O75582 | 6/20 | 0.92 |
| ▸ | PRKG1 | Q13976 | 6/20 | 0.92 |
| ▸ | PKN2 | Q16513 | 6/20 | 0.92 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.92 |
| ▸ | AKT1 | P31749 | 5/20 | 0.92 |
| ▸ | PRKCD | Q05655 | 5/20 | 0.92 |
| ▸ | PRKG2 | Q13237 | 5/20 | 0.92 |
| ▸ | PRKACA | P17612 | 5/20 | 0.92 |
| ▸ | PRKX | P51817 | 5/20 | 0.92 |
| ▸ | SGK2 | Q9HBY8 | 5/20 | 0.92 |
| ▸ | NEK4 | P51957 | 4/20 | 0.92 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.92 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.92 |
| ▸ | CDC42BPA | Q5VT25 | 4/20 | 0.92 |
| ▸ | AKT2 | P31751 | 3/20 | 0.92 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3092517 | 0.96 | ROCK2 (1.00) | ROCK2ROCK1GSK3BCLK4GSK3A | |
| SCHEMBL3111276 | 0.96 | ROCK2 (1.00) | ROCK2ROCK1GSK3BCLK4GSK3A | |
| SCHEMBL20113323 | 0.89 | ROCK2 (0.79) | ROCK2ROCK1GSK3BCLK4GSK3A | |
| SCHEMBL3111251 | 0.86 | ROCK1 (1.00) | ROCK2ROCK1GSK3BCLK4GSK3A | |
| SCHEMBL3109522 | 0.86 | ROCK1 (1.00) | ROCK2ROCK1GSK3BCLK4GSK3A | |
| SCHEMBL3108391 | 0.85 | ROCK2 (0.79) | ROCK2ROCK1GSK3BCLK4GSK3A | |
| SCHEMBL3105352 | 0.84 | ROCK2 (1.00) | ROCK2ROCK1GSK3BCLK4GSK3A | |
| SCHEMBL3112038 | 0.84 | ROCK2 (1.00) | ROCK2ROCK1GSK3BCLK4GSK3A | |
| SCHEMBL3103847 | 0.84 | ROCK2 (0.78) | ROCK2ROCK1GSK3BCLK4GSK3A | |
| SCHEMBL3109328 | 0.84 | ROCK2 (1.00) | ROCK2ROCK1GSK3BCLK4GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895749-B2 | 4-(4-pyridinyl)-benzamides and their use as rock activity modulators | ABBVIE INC. (US) | 2014-11-25 | — | — | US | disclosed |
| EP-2193119-A1 | 4-(4-PYRIDINYL)-BENZAMIDES AND THEIR USE AS ROCK ACTIVITY MODULATORS | Abbott GmbH & Co. KG (DE) | 2010-06-09 | — | — | EP | disclosed |
| WO-2009027392-A1 | 4-(4-PYRIDINYL)-BENZAMIDES AND THEIR USE AS ROCK ACTIVITY MODULATORS | ABBOTT GMBH & CO. KG (DE) | 2009-03-05 | — | — | WO | disclosed |