Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | RHOC | P08134 | 2/20 | 0.40 |
| ▸ | RHOA | P61586 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3657741 | 0.82 | XPO1 (0.43) | ALDH1A1LMNARHOCRHOAADRA2A | |
| SCHEMBL19314147 | 0.79 | MAPT (0.61) | ALDH1A1MEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL8178051 | 0.79 | MEN1 (0.61) | KIF11MEN1KMT2ALMNAHTT | |
| SCHEMBL9515478 | 0.79 | PRSS1 (0.46) | ALDH1A1MEN1KMT2ALMNAHTT | |
| SCHEMBL19669164 | 0.78 | F2 (0.40) | ALDH1A1 | |
| SCHEMBL6236337 | 0.78 | MEN1 (0.55) | KIF11MEN1KMT2ALMNAHTT | |
| SCHEMBL9494550 | 0.78 | TDP1 (0.43) | ALDH1A1CA12CA1 | |
| SCHEMBL2255790 | 0.77 | ALDH1A1 (0.64) | ALDH1A1MEN1KMT2ALMNAHTT | |
| SCHEMBL21542302 | 0.76 | MEN1 (0.54) | KIF11MEN1KMT2ALMNAHTT | |
| SCHEMBL11941008 | 0.76 | HDAC1 (0.39) | KIF11ALDH1A1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212277-A1 | AMINE LINKED MODULATORS OF Y-SECRETASE | Janssen Pharmaceutica, N.V. (BE) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009052350-A1 | AMINE LINKED MODULATORS OF Y-SECRETASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-04-23 | — | — | WO | disclosed |