Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EEF2K | O00418 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.31 |
| ▸ | CDK2 | P24941 | 2/20 | 0.31 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.30 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | CASP7 | P55210 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3650794 | 0.91 | EEF2K (0.39) | EEF2KIKBKBKDM4EALDH1A1HPGD | |
| SCHEMBL3090670 | 0.89 | EEF2K (0.49) | EEF2KIKBKBALDH1A1HPGDBRAF | |
| SCHEMBL3648627 | 0.88 | EEF2K (0.39) | EEF2KIKBKBBRAFHSP90AB1 | |
| SCHEMBL3648990 | 0.86 | EEF2K (0.38) | EEF2KIKBKBKDM4EALDH1A1HPGD | |
| SCHEMBL3650144 | 0.83 | CA1 (0.44) | EEF2KALDH1A1LMNACCNA2CDK2 | |
| SCHEMBL3650817 | 0.83 | KDM4E (0.40) | EEF2KKDM4EALDH1A1HPGDLMNA | |
| SCHEMBL3649298 | 0.82 | ALDH1A1 (0.40) | EEF2KKDM4EALDH1A1HPGDLMNA | |
| SCHEMBL3655704 | 0.82 | BRAF (0.45) | EEF2KKDM4EALDH1A1HPGDBRAF | |
| SCHEMBL3092099 | 0.79 | EEF2K (0.52) | EEF2KIKBKBALDH1A1HPGDBRAF | |
| SCHEMBL3652813 | 0.79 | EEF2K (0.41) | EEF2KIKBKBKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2197886-A1 | 5-CYANO-THIENOPYRIDINES FOR THE TREATMENT OF TUMORS | Merck Patent GmbH (DE) | 2010-06-23 | — | — | EP | claimed |
| WO-2009049743-A1 | 5-CYANO-THIENOPYRIDINES FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2009-04-23 | — | — | WO | claimed |