Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.39 |
| ▸ | ITGAL | P20701 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3018623 | 0.95 | AR (0.53) | ARSMN1; SMN2ALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL3002220 | 0.95 | SMN1; SMN2 (0.48) | ARSMN1; SMN2ALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL3013827 | 0.89 | SMN1; SMN2 (0.51) | ARSMN1; SMN2ALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL3001185 | 0.87 | SMN1; SMN2 (0.51) | ARSMN1; SMN2ALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL3011298 | 0.86 | MAPT (0.55) | ARSMN1; SMN2ALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL3017577 | 0.85 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1L3MBTL1MAPK1LMNA | |
| SCHEMBL3009218 | 0.84 | SMN1; SMN2 (0.45) | ARSMN1; SMN2ALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL3654029 | 0.83 | FABP4 (0.36) | ARALDH1A1L3MBTL1MAPK1LMNA | |
| SCHEMBL3013793 | 0.83 | SMN1; SMN2 (0.53) | ARSMN1; SMN2ALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL3016451 | 0.83 | MAPT (0.50) | SMN1; SMN2ALDH1A1L3MBTL1MAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188272-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV Remynd (BE) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009019295-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2009-02-12 | — | — | WO | disclosed |