Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3653649 | 0.84 | BCL9 (0.41) | MAPTALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL3658188 | 0.84 | BCL9 (0.41) | MAPTALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL3651913 | 0.84 | BCL9 (0.41) | MAPTALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL3657254 | 0.83 | SMN1; SMN2 (0.39) | MAPTALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL3654285 | 0.81 | MAPT (0.38) | MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL3648133 | 0.81 | LMNA (0.41) | MAPTALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL3656222 | 0.79 | SMN1; SMN2 (0.35) | MAPTALDH1A1RAB9ASMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL3655804 | 0.79 | CYP1A2 (0.36) | RAB9A | |
| SCHEMBL3707040 | 0.79 | ROCK1 (0.37) | MAPT | |
| SCHEMBL3657543 | 0.79 | NPC1 (0.40) | MAPTALDH1A1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212282-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009052065-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-04-23 | — | — | WO | disclosed |