Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.68 |
| ▸ | RAB9A | P51151 | 3/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.68 |
| ▸ | PKM | P14618 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | MITF | O75030 | 1/20 | 0.64 |
| ▸ | KDR | P35968 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | GRM4 | Q14833 | 7/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | AXL | P30530 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30686047 | 0.91 | GRM4 (0.65) | NPC1RAB9ASMN1; SMN2PKMMAPT | |
| SCHEMBL10415452 | 0.91 | GRM4 (0.65) | NPC1RAB9ASMN1; SMN2PKMMAPT | |
| SCHEMBL2535716 | 0.85 | GRM4 (0.67) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL3092361 | 0.81 | SMN1; SMN2 (1.00) | NPC1RAB9ASMN1; SMN2PKMMAPT | |
| SCHEMBL2533682 | 0.80 | NPC1 (0.71) | NPC1RAB9ASMN1; SMN2PKMMAPT | |
| SCHEMBL30904871 | 0.80 | NPC1 (0.71) | NPC1RAB9ASMN1; SMN2PKMMAPT | |
| SCHEMBL27930549 | 0.79 | PTGS1 (0.56) | NPC1RAB9ASMN1; SMN2PKMMAPT | |
| SCHEMBL6630361 | 0.78 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2PKMMAPT | |
| SCHEMBL8215155 | 0.78 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2PKMMAPT | |
| SCHEMBL231897 | 0.78 | KDR (0.78) | NPC1RAB9ASMN1; SMN2PKMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593434-A1 | PYRIDINE COMPOUNDS AS SODIUM CHANNEL BLOCKERS | Purdue Pharma LP (US) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007836-A1 | PYRIDINE COMPOUNDS AS SODIUM CHANNEL BLOCKERS | PURDUE PHARMA .LP. (US) | 2012-01-19 | — | — | WO | disclosed |