Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 17/20 | 0.66 |
| ▸ | PIK3CA | P42336 | 18/20 | 0.64 |
| ▸ | PIK3CB | P42338 | 16/20 | 0.64 |
| ▸ | PIK3CG | P48736 | 16/20 | 0.64 |
| ▸ | MTOR | P42345 | 3/20 | 0.64 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.64 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.64 |
| ▸ | PLK4 | O00444 | 1/20 | 0.64 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.64 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.64 |
| ▸ | GAK | O14976 | 1/20 | 0.64 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.64 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.64 |
| ▸ | STK16 | O75716 | 1/20 | 0.64 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.64 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.64 |
| ▸ | NQO2 | P16083 | 1/20 | 0.64 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.64 |
| ▸ | JAK1 | P23458 | 1/20 | 0.64 |
| ▸ | TYK2 | P29597 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3656793 | 0.91 | PIK3CA (0.63) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL14898482 | 0.90 | PIK3CD (0.52) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL8072173 | 0.87 | PIK3CD (0.51) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL8068198 | 0.86 | PIK3CD (0.66) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL13059918 | 0.86 | PIK3CD (0.50) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL14898410 | 0.80 | PIK3CA (0.49) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL29482127 | 0.80 | PIK3CD (1.00) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL391747 | 0.80 | PIK3CD (1.00) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL190513 | 0.80 | PIK3CA (0.95) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL15006513 | 0.79 | ABCC4 (0.65) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2214675-B1 | PROCESS FOR MAKING THIENOPYRIMIDINE COMPOUNDS | GENENTECH INC (US) | 2013-11-20 | — | — | EP | claimed |
| US-8354528-B2 | Process for making thienopyrimidine compounds | GENENTECH, INC. (US) | 2013-01-15 | — | — | US | claimed |
| US-20100292468-A1 | PROCESS FOR MAKING THIENOPYRIMIDINE COMPOUNDS | GENETECH, INC | 2010-11-18 | — | — | US | claimed |
| EP-2214675-A1 | PROCESS FOR MAKING THIENOPYRIMIDINE COMPOUNDS | Genentech, Inc. (US) | 2010-08-11 | — | — | EP | claimed |
| WO-2009055730-A1 | PROCESS FOR MAKING THIENOPYRIMIDINE COMPOUNDS | GENENTECH, INC. (US) | 2009-04-30 | — | — | WO | claimed |
| EP-2214675-B1 | PROCESS FOR MAKING THIENOPYRIMIDINE COMPOUNDS | GENENTECH INC (US) | 2013-11-20 | — | — | EP | disclosed |
| US-20130109852-A1 | PROCESS FOR MAKING THIENOPYRIMIDINE COMPOUNDS | GENENTECH, INC. (US) | 2013-05-02 | — | — | US | disclosed |
| US-20130109852-A1 | PROCESS FOR MAKING THIENOPYRIMIDINE COMPOUNDS | GENENTECH, INC. (US) | 2013-05-02 | — | — | US | disclosed |
| US-20130109852-A1 | PROCESS FOR MAKING THIENOPYRIMIDINE COMPOUNDS | GENENTECH, INC. (US) | 2013-05-02 | — | — | US | disclosed |
| US-8431694-B1 | Process for making thienopyrimidine compounds | GENENTECH, INC. (US) | 2013-04-30 | — | — | US | disclosed |
| US-8431694-B1 | Process for making thienopyrimidine compounds | GENENTECH, INC. (US) | 2013-04-30 | — | — | US | disclosed |
| US-8431694-B1 | Process for making thienopyrimidine compounds | GENENTECH, INC. (US) | 2013-04-30 | — | — | US | disclosed |
| US-8354528-B2 | Process for making thienopyrimidine compounds | GENENTECH, INC. (US) | 2013-01-15 | — | — | US | disclosed |
| US-8354528-B2 | Process for making thienopyrimidine compounds | GENENTECH, INC. (US) | 2013-01-15 | — | — | US | disclosed |
| US-20100292468-A1 | PROCESS FOR MAKING THIENOPYRIMIDINE COMPOUNDS | GENETECH, INC | 2010-11-18 | — | — | US | disclosed |
| US-20100292468-A1 | PROCESS FOR MAKING THIENOPYRIMIDINE COMPOUNDS | GENETECH, INC | 2010-11-18 | — | — | US | disclosed |
| US-20100292468-A1 | PROCESS FOR MAKING THIENOPYRIMIDINE COMPOUNDS | GENETECH, INC | 2010-11-18 | — | — | US | disclosed |
| EP-2214675-A1 | PROCESS FOR MAKING THIENOPYRIMIDINE COMPOUNDS | Genentech, Inc. (US) | 2010-08-11 | — | — | EP | disclosed |
| WO-2009055730-A1 | PROCESS FOR MAKING THIENOPYRIMIDINE COMPOUNDS | GENENTECH, INC. (US) | 2009-04-30 | — | — | WO | disclosed |
| WO-2009055730-A1 | PROCESS FOR MAKING THIENOPYRIMIDINE COMPOUNDS | GENENTECH, INC. (US) | 2009-04-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292468-A1 | PROCESS FOR MAKING THIENOPYRIMIDINE COMPOUNDS | PIK3CA, PIK3CD, PIK3CB | PIK3CD 2/4885PIK3CA 1/4885PIK3CB 3/4885 |
| US-20130109852-A1 | PROCESS FOR MAKING THIENOPYRIMIDINE COMPOUNDS | PIK3CA, PIK3CD, PIK3CB | PIK3CD 2/4885PIK3CA 1/4885PIK3CB 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.