Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 7/20 | 0.46 |
| ▸ | RXRG | P48443 | 7/20 | 0.46 |
| ▸ | RXRB | P28702 | 6/20 | 0.46 |
| ▸ | PPARA | Q07869 | 6/20 | 0.43 |
| ▸ | PPARD | Q03181 | 8/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3656696 | 0.88 | PPARA (0.38) | RXRARXRGRXRBPPARAPPARD | |
| SCHEMBL3656006 | 0.83 | PSEN1 (0.59) | RXRARXRGRXRBPPARAPSEN1 | |
| SCHEMBL4540532 | 0.76 | RXRA (0.47) | RXRARXRGRXRBPPARAPPARD | |
| SCHEMBL3657611 | 0.75 | PSEN1 (0.61) | RXRARXRGRXRBPPARAPSEN1 | |
| SCHEMBL491483 | 0.71 | RXRA (0.71) | RXRARXRGRXRBPPARAPPARD | |
| SCHEMBL8047507 | 0.71 | GCGR (0.48) | RXRARXRGRXRBPPARAPPARD | |
| SCHEMBL3656015 | 0.71 | RXRA (0.47) | RXRARXRGRXRBPPARAPPARD | |
| SCHEMBL3651166 | 0.71 | PSEN1 (0.48) | RXRARXRGRXRBPSEN1PSEN2 | |
| SCHEMBL11989119 | 0.70 | RXRA (0.49) | RXRARXRGRXRBPPARAPPARD | |
| SCHEMBL11988676 | 0.69 | PSEN1 (0.40) | RXRARXRGRXRBPPARAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212277-A1 | AMINE LINKED MODULATORS OF Y-SECRETASE | Janssen Pharmaceutica, N.V. (BE) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009052350-A1 | AMINE LINKED MODULATORS OF Y-SECRETASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-04-23 | — | — | WO | disclosed |