Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.66 |
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.64 |
| ▸ | AR | P10275 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | PREP | P48147 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24564636 | 0.86 | SIGMAR1 (0.66) | SIGMAR1HRH3ARMEN1ALDH1A1 | |
| SCHEMBL24564633 | 0.84 | SIGMAR1 (0.60) | SIGMAR1HRH3ARALDH1A1 | |
| SCHEMBL24564680 | 0.83 | HRH3 (0.64) | SIGMAR1HRH3ARMEN1ALDH1A1 | |
| SCHEMBL24564566 | 0.82 | HRH3 (0.63) | SIGMAR1HRH3ARMEN1ALDH1A1 | |
| SCHEMBL15314413 | 0.82 | SIGMAR1 (0.73) | SIGMAR1HRH3ARMEN1ALDH1A1 | |
| SCHEMBL15314418 | 0.82 | SIGMAR1 (0.73) | SIGMAR1HRH3ARMEN1ALDH1A1 | |
| SCHEMBL5360252 | 0.82 | SIGMAR1 (0.64) | SIGMAR1HRH3ARMEN1ALDH1A1 | |
| SCHEMBL4868100 | 0.82 | SIGMAR1 (0.64) | SIGMAR1HRH3ARMEN1ALDH1A1 | |
| SCHEMBL10123280 | 0.82 | SIGMAR1 (0.76) | SIGMAR1HRH3PREP | |
| SCHEMBL870758 | 0.82 | SIGMAR1 (0.76) | SIGMAR1HRH3PREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426420-B2 | Heterocyclic pyrazole-carboxamidesas P2Y12 antagonists | SANOFI (FR) | 2013-04-23 | — | — | US | claimed |
| EP-2238128-B1 | HETEROCYCLIC PYRAZOLE-CARBOXAMIDES AS P2Y12 ANTAGONISTS | SANOFI SA (FR) | 2012-08-22 | — | — | EP | claimed |
| EP-2238128-A2 | HETEROCYCLIC PYRAZOLE-CARBOXAMIDES AS P2Y12 ANTAGONISTS | Sanofi-Aventis (FR) | 2010-10-13 | — | — | EP | claimed |
| WO-2009080226-A2 | HETEROCYCLIC PYRAZOLE-CARBOXAMIDES AS P2Y12 ANTAGONISTS | SANOFIS-AVENTIS (FR) | 2009-07-02 | — | — | WO | claimed |
| US-8426420-B2 | Heterocyclic pyrazole-carboxamidesas P2Y12 antagonists | SANOFI (FR) | 2013-04-23 | — | — | US | disclosed |
| EP-2238128-B1 | HETEROCYCLIC PYRAZOLE-CARBOXAMIDES AS P2Y12 ANTAGONISTS | SANOFI SA (FR) | 2012-08-22 | — | — | EP | disclosed |
| EP-2238128-A2 | HETEROCYCLIC PYRAZOLE-CARBOXAMIDES AS P2Y12 ANTAGONISTS | Sanofi-Aventis (FR) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009080226-A2 | HETEROCYCLIC PYRAZOLE-CARBOXAMIDES AS P2Y12 ANTAGONISTS | SANOFIS-AVENTIS (FR) | 2009-07-02 | — | — | WO | disclosed |