Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALB | P02768 | 1/20 | 0.44 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.44 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3801494 | 0.83 | APP (0.38) | TTRKDM4EMEN1USP2ALDH1A1 | |
| SCHEMBL475505 | 0.81 | TTR (0.57) | TTRKDM4EMEN1USP2ALDH1A1 | |
| SCHEMBL19325888 | 0.79 | IDO1 (0.45) | TTRKDM4EMEN1USP2ALDH1A1 | |
| SCHEMBL19320830 | 0.79 | PTGER1 (0.44) | TTRKDM4EMEN1USP2ALDH1A1 | |
| SCHEMBL3657877 | 0.78 | AKR1C3 (0.43) | TTRKDM4EMEN1USP2ALDH1A1 | |
| SCHEMBL3071028 | 0.76 | TTR (0.46) | TTRKDM4EMEN1USP2ALDH1A1 | |
| SCHEMBL21711610 | 0.74 | MRGPRX4 (0.47) | KMT2APTGER1AKR1C3MRGPRX4AKR1C2 | |
| SCHEMBL411705 | 0.72 | BCL2L1 (0.62) | TTRKDM4EMEN1USP2ALDH1A1 | |
| SCHEMBL16195147 | 0.71 | DHODH (0.51) | TTRKDM4EMEN1USP2ALDH1A1 | |
| SCHEMBL475628 | 0.71 | ALPL (0.51) | TTRKDM4EMEN1USP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2215049-A1 | P2X3, RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN | Merck Sharp & Dohme Corp. (US) | 2010-08-11 | — | — | EP | disclosed |
| WO-2009058298-A1 | P2X3, RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN | MERCK & CO., INC. (US) | 2009-05-07 | — | — | WO | disclosed |